1. Paucity of CD34-positive cells and increased expression of high-mobility group box 1 in coronary thrombus with type 2 diabetes mellitus
- Author
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Yamashita, Atsushi, Nishihira, Kensaku, Matsuura, Yunosuke, Ito, Takashi, Kawahara, Kouichi, Hatakeyama, Kinta, Hashiguchi, Teruto, Maruyama, Ikuro, Yagi, Hideo, Matsumoto, Masanori, Fujimura, Yoshihiro, Kitamura, Kazuo, Shibata, Yoshisato, and Asada, Yujiro
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CD34 antigen , *GENE expression , *CORONARY disease , *PEOPLE with diabetes , *IMMUNOHISTOCHEMISTRY , *BLOOD platelets , *ERYTHROCYTES , *NEUTROPHILS - Abstract
Abstract: To examine the presence of CD34-positive cells and intranuclear factors in acute coronary thrombi, we compared thrombi in patients with type 2 diabetes mellitus (DM, n = 21) and without DM (n = 29). Immunohistochemical staining revealed the constitutive presence of platelets, fibrin, erythrocytes, neutrophils, extracellular high-mobility group box 1 (HMGB-1), and histone H3 in all thrombi. There were significantly more oval or flat CD34-positive cells and significantly larger HMGB-1-positive areas in the thrombi from patients with DM. The flat CD34-positive cells expressed ecto-nucleoside triphosphate diphosphohydrolase (a platelet aggregation inhibitor). The number of CD34-positive cells was negatively correlated with the serum levels of glucose and hemoglobin A1c, whereas the HMGB-1-positive area was positively correlated with the levels of serum glucose. The paucity of CD34-positive cells and the high levels of HMGB-1 expression in acute coronary thrombi from patients with type 2 DM could facilitate thrombus formation. [Copyright &y& Elsevier]
- Published
- 2012
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