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15 results on '"Mukamal, Kenneth J."'

2. Fibroblast growth factor 23, left ventricular mass, and left ventricular hypertrophy in community-dwelling older adults

Author

Jovanovich, Anna, Ix, Joachim H, Gottdiener, John, McFann, Kim, Katz, Ronit, Kestenbaum, Bryan, de Boer, Ian H, Sarnak, Mark, Shlipak, Michael G, Mukamal, Kenneth J, Siscovick, David, and Chonchol, Michel

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Aging, Prevention, Kidney Disease, Hypertension, Clinical Research, Renal and urogenital, Cardiovascular, Good Health and Well Being, Aged, Female, Fibroblast Growth Factor-23, Fibroblast Growth Factors, Heart Ventricles, Humans, Hypertrophy, Left Ventricular, Longitudinal Studies, Male, Renal Insufficiency, Chronic, Risk Factors, Ultrasonography, Left ventricular mass, Left ventricular hypertrophy, Chronic kidney disease, Fibroblast growth factor 23, Older adults, Cardiovascular disease, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

ObjectivesIn chronic kidney disease (CKD), high FGF23 concentrations are associated with left ventricular hypertrophy (LVH), cardiovascular events, and death. The associations of FGF23 with left ventricular mass (LVM) and LVH in the general population and the influence of CKD remains uncertain.MethodsC-terminal plasma FGF23 concentrations were measured, and LVM and LVH evaluated by echocardiogram among 2255 individuals ≥65 years in the Cardiovascular Health Study. Linear regression analysis adjusting for demographics, cardiovascular, and kidney related risk factors examined the associations of FGF23 concentrations with LVM. Analyses were stratified by CKD status and adjusted linear and logistic regression analysis explored the associations of FGF23 with LVM and LVH.ResultsAmong the entire cohort, higher FGF23 concentrations were associated with greater LVM in adjusted analyses (β = 6.71 [95% CI 4.35-9.01] g per doubling of FGF23). 32% (n = 624) had CKD (eGFR 30 mg/g). Associations were stronger among participants with CKD (p interaction = 0.006): LVM β = 9.71 [95% CI 5.86-13.56] g per doubling of FGF23 compared to those without CKD (β = 3.44 [95% CI 0.77, 6.11] g per doubling of FGF23). While there was no significant interaction between FGF23 and CKD for LVH (p interaction = 0.25), the OR (1.46 95% CI [1.20-1.77]) in the CKD group was statistically significant and of larger magnitude than the OR for in the no CKD group (1.12 [95% CI 0.97-1.48]).ConclusionIn a large cohort of older community-dwelling adults, higher FGF23 concentrations were associated with greater LVM and LVH with stronger relationships in participants with CKD.

Published
2013

9. Fibrosis-related biomarkers and large and small vessel disease: The Cardiovascular Health Study

Author

Agarwal, Isha, primary, Arnold, Alice, additional, Glazer, Nicole L., additional, Barasch, Eddy, additional, Djousse, Luc, additional, Fitzpatrick, Annette L., additional, Gottdiener, John S., additional, Ix, Joachim H., additional, Jensen, Richard A., additional, Kizer, Jorge R., additional, Rimm, Eric B., additional, Siscovick, David S., additional, Tracy, Russell P., additional, Wong, Tien Y., additional, and Mukamal, Kenneth J., additional

Published
2015
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13. Genetic determinants of the ankle-brachial index: A meta-analysis of a cardiovascular candidate gene 50K SNP panel in the candidate gene association resource (CARe) consortium

Author

Wassel, Christina L., primary, Lamina, Claudia, additional, Nambi, Vijay, additional, Coassin, Stefan, additional, Mukamal, Kenneth J., additional, Ganesh, Santhi K., additional, Jacobs, David R., additional, Franceschini, Nora, additional, Papanicolaou, George J., additional, Gibson, Quince, additional, Yanek, Lisa R., additional, van der Harst, Pim, additional, Ferguson, Jane F., additional, Crawford, Dana C., additional, Waite, Lindsay L., additional, Allison, Matthew A., additional, Criqui, Michael H., additional, McDermott, Mary M., additional, Mehra, Reena, additional, Cupples, L. Adrienne, additional, Hwang, Shih-Jen, additional, Redline, Susan, additional, Kaplan, Robert C., additional, Heiss, Gerardo, additional, Rotter, Jerome I., additional, Boerwinkle, Eric, additional, Taylor, Herman A., additional, Eraso, Luis H., additional, Haun, Margot, additional, Li, Mingyao, additional, Meisinger, Christa, additional, O’Connell, Jeffrey R., additional, Shuldiner, Alan R., additional, Tybjærg-Hansen, Anne, additional, Frikke-Schmidt, Ruth, additional, Kollerits, Barbara, additional, Rantner, Barbara, additional, Dieplinger, Benjamin, additional, Stadler, Marietta, additional, Mueller, Thomas, additional, Haltmayer, Meinhard, additional, Klein-Weigel, Peter, additional, Summerer, Monika, additional, Wichmann, H.-Erich, additional, Asselbergs, Folkert W., additional, Navis, Gerjan, additional, Leach, Irene Mateo, additional, Brown-Gentry, Kristin, additional, Goodloe, Robert, additional, Assimes, Themistocles L., additional, Becker, Diane M., additional, Cooke, John P., additional, Absher, Devin M., additional, Olin, Jeffrey W., additional, Mitchell, Braxton D., additional, Reilly, Muredach P., additional, Mohler, Emile R., additional, North, Kari E., additional, Reiner, Alexander P., additional, Kronenberg, Florian, additional, and Murabito, Joanne M., additional

Published
2012
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