1. Biological determinants of serum ICAM-1, E-selectin, P-selectin and L-selectin levels in healthy subjects: the Stanislas study
- Author
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Daniel Lambert, Anne Ponthieux, Suzanne Droesch, Sophie Visvikis, Nadia Haddy, Bernard Herbeth, Génétique épidémiologique et moléculaire des pathologies cardiovasculaires, and Université Pierre et Marie Curie - Paris 6 (UPMC)-IFR14-Institut National de la Santé et de la Recherche Médicale (INSERM)
- Subjects
Blood Glucose ,Male ,P-selectin ,MESH: Apolipoprotein A-I ,030204 cardiovascular system & hematology ,MESH: Regression Analysis ,Body Mass Index ,Leukocyte Count ,0302 clinical medicine ,MESH: Alkaline Phosphatase ,MESH: Child ,Medicine ,MESH: L-Selectin ,Homeostasis ,L-Selectin ,Child ,2. Zero hunger ,0303 health sciences ,ICAM-1 ,MESH: Middle Aged ,biology ,Smoking ,Age Factors ,MESH: Enzyme-Linked Immunosorbent Assay ,Middle Aged ,Intercellular Adhesion Molecule-1 ,3. Good health ,P-Selectin ,C-Reactive Protein ,MESH: Homeostasis ,Child, Preschool ,MESH: P-Selectin ,Alkaline phosphatase ,Regression Analysis ,L-selectin ,Female ,Cardiology and Cardiovascular Medicine ,MESH: Contraceptives, Oral ,E-Selectin ,Adult ,medicine.medical_specialty ,MESH: E-Selectin ,MESH: Smoking ,Adolescent ,Aspartate transaminase ,Enzyme-Linked Immunosorbent Assay ,MESH: Erythrocyte Count ,MESH: Body Mass Index ,03 medical and health sciences ,MESH: Aspartate Aminotransferases ,Sex Factors ,MESH: Sex Factors ,Internal medicine ,E-selectin ,MESH: C-Reactive Protein ,Humans ,MESH: Platelet Count ,Aspartate Aminotransferases ,030304 developmental biology ,MESH: Adolescent ,MESH: Age Factors ,MESH: Humans ,Apolipoprotein A-I ,business.industry ,Platelet Count ,Tumor Necrosis Factor-alpha ,MESH: Intercellular Adhesion Molecule-1 ,C-reactive protein ,MESH: Child, Preschool ,MESH: Adult ,Alkaline Phosphatase ,MESH: Male ,Endocrinology ,MESH: Leukocyte Count ,MESH: Tumor Necrosis Factor-alpha ,Immunology ,biology.protein ,MESH: Blood Glucose ,Erythrocyte Count ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,business ,Body mass index ,MESH: Female ,Contraceptives, Oral - Abstract
Background: Circulating levels of adhesion molecules increase in various inflammation-related diseases, such as atherosclerosis. However, data about factors influencing their concentrations in physiological conditions are scarce. Methods: We have studied the determinants of serum levels of intercellular adhesion molecule-1 (ICAM-1), E-selectin, P-selectin and L-selectin in a sample of healthy individuals: 303 children (4–17 years) and 493 adults (18–55 years). The concentrations of these molecules have been measured by enzyme-linked immunosorbant assay. Results: As far as the children are concerned, a decrease in the levels of ICAM-1, E-selectin, P-selectin and L-selectin has been noticed for both boys and girls aged 4–17 years, without any difference between genders. For the adults, no age-related variation has been found for the ICAM-1, E-selectin and P-selectin levels, while the L-selectin level decreased until 55 years old. In the adult group, no sex-related difference in the concentrations of ICAM-1, E-selectin and L-selectin has been seen. As to the P-selectin level, men had significantly higher levels than women. Multiple regression analysis showed that smoking, homeostasis model assessment (HOMA) index, aspartate aminotransferase (AST), alkaline phosphatase (ALP) and C-reactive protein (CRP) were significant positive determinants of the ICAM-1 concentration, whereas age and apo AI were negative ones. The E-selectin level was positively associated with body mass index (BMI), leukocyte, platelet and erythrocyte counts, glucose, ALP and tumor necrosis factor-alpha (TNF-α), and negatively related to the use of oral contraceptive (OC). Positive determinants of the P-selectin concentration were leukocyte, platelet and erythrocyte counts, whereas sex, the use of oral contraceptive, glucose and TNF-α were negative determinants of P-selectin. Only two determinants have been noticed for the concentration of serum L-selectin: age, which was negatively correlated, and leukocyte count, which was positively associated. Conclusion: Our study contributes to the understanding of the regulation of adhesion molecules in physiological conditions.
- Published
- 2003
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