1. Lipoprotein(a) and family history for cardiovascular disease in paediatric patients: A new frontier in cardiovascular risk stratification. Data from the LIPIGEN paediatric group
- Author
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Cristina Pederiva, Maria Elena Capra, Giacomo Biasucci, Giuseppe Banderali, Enrico Fabrizi, Marta Gazzotti, Manuela Casula, Alberico L. Catapano, Marcello Arca, Maurizio Averna, Stefano Bertolini, Sebastiano Calandra, Alberico Luigi Catapano, Patrizia Tarugi, Fabio Pellegatta, Andrea Bartuli, Claudio Borghi, Paolo Calabrò, Francesca Carubbi, Francesco Cipollone, Nadia Citroni, Maria Del Ben, Giuliana Fortunato, Ornella Guardamagna, Arcangelo Iannuzzi, Gabriella Iannuzzo, Lorenzo Iughetti, Giuseppe Mandraffino, Lorenzo Maroni, Giuliana Mombelli, Sandro Muntoni, Gianfranco Parati, Angelina Passaro, Livia Pisciotta, Arturo Pujia, Francesco Purrello, Anna Rita Roscini, Riccardo Sarzani, Patrizia Suppressa, Josè Pablo Werba, Sabina Zambon, Maria Grazia Zenti, Massimiliano Allevi, Renata Auricchio, Davide Baldera, Patrizia Bruzzi, Marco Bucci, Paola Sabrina Buonuomo, Angelo Baldassarre Cefalù, Giuseppe Covetti, Sergio D'Addato, Maria Donata Di Taranto, Roberto Franceschi, Fabio Fimiani, Simonetta Genovesi, Liliana Grigore, Graziana Lupattelli, Sara Madaghiele, Giulia Massini, Ilenia Minicocci, Tiziana Montalcini, Fabio Nascimbeni, Chiara Pavanello, Francesco Massimo Perla, Gaia Peroni, Elena Sani, Roberto Scicali, Arianna Toscano, Giovanni Battista Vigna, Alberto Zambon, Federica Galimberti, Elena Olmastroni, and Veronica Zampoleri
- Subjects
Male ,Adolescent ,Family history ,High cardiovascular risk ,Paediatric FH ,Lp(a) ,Children/adolescents ,Premature CVD ,Cholesterol, LDL ,Hyperlipoproteinemia Type II ,Cardiovascular Diseases ,Heart Disease Risk Factors ,Risk Factors ,Humans ,Female ,Cardiology and Cardiovascular Medicine ,Child ,Lipoprotein(a) - Abstract
Little is known about the role of Lp(a) in the assessment of cardiovascular risk in the paediatric population. Trying to clarify the clinical relevance of Lp(a) in risk stratification, the aim of the study is to evaluate the association between Lp(a) plasma levels in children with familial hypercholesterolaemia (FH) and positive family history for premature cardiovascular disease (pCVD) in first- and second-degree relatives.653 Caucasian children and adolescents (334 females and 319 males), aged 2-17 years, with diagnosis of FH from a paediatric cohort included in the LIPIGEN Network, were selected. We compared family history of pCVD, lipid and genetic profile in two groups based on Lp(a) levels below or above 30 mg/dL. To determine the independent predictors of pCVD, a multivariate logistic regression was used, with all clinical characteristics and blood measurements as predictors.Subjects with Lp(a) 30 mg/dl more frequently reported positive family history of pCVD compared to subjects with Lp(a)≤30 mg/dl (69.90% vs 36.66%, p 0.0001), while did not show differences in terms of median [interquartile range] LDL-cholesterol level (153.00 [88.00 vs 164.50 [90.25] mg/dL, p = 0.3105). In the regression analysis, Lp(a) 30 mg/dl was an independent predictor of family history of pCVD. Comparing subjects with or without family history of pCVD, we reported significant differences for Lp(a) 30 mg/dl (46.25% vs 17.65%, p 0.0001), FH genetic mutation (50.48% vs 40.75%, p = 0,0157), as well as for LDL-cholesterol (p = 0.0013) and total cholesterol (p = 0.0101).Children/adolescents with FH and Lp(a) 30 mg/dl where more likely to have a positive family history of pCVD. Lp(a) screening in children and adolescents with FH may enhance risk assessment and help identify those subjects, children and relatives, at increased pCVD risk.
- Published
- 2021