1. Reduced Expression of IL-1β and IL-18 Proinflammatory Interleukins Increases the Risk of Developing Cervical Cancer.
- Author
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Matamoros JA, da Silva MIF, de Moura PMMF, Leitão MDCG, and Coimbra EC
- Subjects
- Biomarkers, Tumor, Case-Control Studies, Cervix Uteri metabolism, Female, Follow-Up Studies, Humans, Interleukin-18 genetics, Interleukin-1beta genetics, Prognosis, Risk Factors, Uterine Cervical Dysplasia genetics, Uterine Cervical Dysplasia metabolism, Uterine Cervical Neoplasms genetics, Uterine Cervical Neoplasms metabolism, Cervix Uteri pathology, Interleukin-18 metabolism, Interleukin-1beta metabolism, Uterine Cervical Dysplasia pathology, Uterine Cervical Neoplasms pathology
- Abstract
Background: The objective of this study was to analyze the gene expression profile of the proinflammatory interleukins, (IL-1β and IL-18) in patients with premalignant lesions and cervical cancer. Methods: Total IL-1β and IL-18 mRNA was quantified by qPCR to obtain the expression data in cervical tissues. A total of 74 cervical biopsies were obtained from women undergoing a colposcopy. The samples were divided into: normal (19), low level lesions (LSIL) or NIC I (17), high level lesions (HSIL) or CIN II and CIN III (29) and cancer (9). The normal cervical tissue samples were included as controls. The OR and 95% CI were calculated for the determination of the risk of progression between each type of lesion and cancer using logistic regression. Results: The results showed that an increase in the risk of progression of pre-neoplastic lesions to cancer was between 2.5 and 2.08 times higher in women with lower IL-1β and IL-18 expression, respectively. Conclusions: This study provided evidence that IL-1β and IL-18 are potential biomarkers that can be explored in further studies for monitoring the evolution of pre-neoplastic lesions and avoiding overtreatment or undertreatment of the patients.
- Published
- 2019
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