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Start Over Author "Umaporn Limothai" Journal asian pacific journal of cancer prevention : apjcp
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1. Single Nucleotide Polymorphism of Interferon Lambda-4 Gene is not Associated with Treatment Response to Pegylated Interferon in Thai Patients with Chronic Hepatitis B

Author

Pisit Tangkijvanich, Rujipat Wasitthankasem, Yong Poovorawan, and Umaporn Limothai

Subjects
Adult, Male, Cancer Research, HBsAg, Hepatitis B virus, Epidemiology, Alpha interferon, Single-nucleotide polymorphism, Biology, Interferon alpha-2, medicine.disease_cause, Antiviral Agents, Polymorphism, Single Nucleotide, Polyethylene Glycols, Hepatitis B, Chronic, Pegylated interferon, Genotype, medicine, Humans, Genotyping, Neoplasm Staging, Retrospective Studies, Interleukins, Public Health, Environmental and Occupational Health, virus diseases, Interferon-alpha, Hepatitis B, medicine.disease, Prognosis, digestive system diseases, Recombinant Proteins, Oncology, Immunology, Female, medicine.drug, Follow-Up Studies
Abstract

The single nucleotide polymorphism (SNP) ss469415590 in the interferon lambda-4 (IFNL4) gene has recently been reported to have an association with treatment response in chronic hepatitis C. However, any importance of the SNP in association with response to pegylated interferon (PEG-IFN) therapy in patients with chronic hepatitis B (CHB) is unclear. We retrospectively analyzed data for Thai patients with CHB treated with PEG-IFN for 48 weeks. Virological response (VR) for HBeAg-positive CHB was defined as HBeAg seroconversion plus HBV DNA level

Published
2015

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