1. Increased Micronucleus Frequency in Peripheral Blood Lymphocytes Contributes to Cancer Risk in the Methyl Isocyanate-Affected Population of Bhopal
- Author
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Narayanan Ganesh, Tahir M. Malla, Sameena Akhter, Chinnu Sugavanam Senthilkumar, and Nand Kishore Sah
- Subjects
Male ,Cancer Research ,Epidemiology ,Physiology ,Methyl isocyanate ,Toxicology ,chemistry.chemical_compound ,Pregnancy ,Risk Factors ,Neoplasms ,Medicine ,Lymphocytes ,Survivors ,Child ,education.field_of_study ,Micronucleus Tests ,Smoking ,Middle Aged ,Oncology ,Maternal Exposure ,Prenatal Exposure Delayed Effects ,Paternal Exposure ,Micronucleus test ,Female ,Cell Nucleus Division ,Adult ,Tobacco, Smokeless ,Adolescent ,Alcohol Drinking ,Offspring ,Population ,Bhopal Accidental Release ,India ,Young Adult ,Sex Factors ,Humans ,education ,Life Style ,Micronuclei, Chromosome-Defective ,business.industry ,Public Health, Environmental and Occupational Health ,Environmental Exposure ,Peripheral blood ,chemistry ,Case-Control Studies ,Cancer risk ,Lifestyle habits ,Micronucleus ,business ,Isocyanates - Abstract
The Bhopal gas tragedy involving methyl isocyanate (MIC) is one of the most horrific industrial accidents in recent decades. We investigated the genotoxic effects of MIC in long-term survivors and their offspring born after the 1984 occurrence. There are a few cytogenetic reports showing genetic damage in the MIC-exposed survivors, but there is no information about the associated cancer risk. The same is true about offspring. For the first time, we here assessed the micronucleus (MN) frequency using cytokinesis-blocked micronucleus (CBMN) assay to predict cancer risk in the MIC-affected population of Bhopal. A total of 92 healthy volunteers (46 MICaffected and 46 controls) from Bhopal and various regions of India were studied taking gender and age into consideration. Binucleated lymphocytes with micronuclei (BNMN), total number of micronuclei in lymphocytes (MNL), and nuclear division index (NDI) frequencies and their relationship to age, gender and several lifestyle variabilities (smoking, alcohol consumption and tobacco-chewing) were investigated. Our observations showed relatively higher BNMN and MNL (P
- Published
- 2015
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