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Noise in the immunohematological investigations can be described as a false reactivity of red blood cells (RBCs) in serologic testing that is not related to the interaction of RBC antigens and antibodies that the test system is intended to detect. These false-positive reactions can cause confusion during the cross-matching and RBC antibody screening and may result in delays in patient transfusion. Although these antibodies are predominantly clinically insignificant, proper laboratory work-up is indicated to avoid misidentification of a clinically significant antibody as a noise. In this report, we describe the three rare cases where the reactivity was found against the ingredients of the column matrix (glass beads). It is imperative that such reactivity is recognized and resolved during the investigation of blood group discrepancies, positive RBC antibody screens and in cases of positive cross-matches. [ABSTRACT FROM AUTHOR]