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Objective: The aim of the study was to evaluate the analgesic activity of Acacia catechu heartwood extracts on Swiss albino mice using hot plate and tail immersion method. Methods: In this study, we used the aqueous and methanol extracts of heartwood of A. catechu to evaluate its analgesic activity. The aqueous extract was achieved by doubled distillation method and the methanol extract was achieved by cold maceration method. The mice were divided into four groups, each group consisting of six animals. Doses of 50, 100, and 300 mg/kg, p.o. of both the extracts of A. catechu were given to the mice. The responses were noted at 0, 15, 30, and 60 min. Results: The results of both the methods were quick similar but differ based on extracts. The aqueous extract of A. catechu showed a much better yield of analgesic activity as compared to the methanol extract. The data were analyzed by graph using two-way analysis of variance, which showed the dose-dependent pain resistance. Conclusion: The study confirmed the potency of A. catechu in pain management and points the future development to be conducted on it.

Background: Pain is defined physical or mental depending on it source of origin and pain treated with anti-anxiety, antidepressant, and analgesic medicine. Andrographis paniculata locally called kalmegh of Acanthaceae family and Vitex negundo locally called nirgundi of Lamiaceae, both medicinal plants which yield the therapeutic compound and herbal drug used cure diseases. Methods: The analgesic activity was performed by hot plat and tail immersion method. The present study extract performs models plants 50 Swiss albino mice four groups of each five animals. This experimental animal administered with extract intraperitoneal at dose level 50, 100, and 300 mg/kg used as reference drugs diclofenac sodium-induced time test using albino mice as experimental animal. Results: Medicinal plants ethanolic extract contains reducing carbohydrate, flavonoids, tannins, and triterpenoids. The sample comparable antibacterial cytotoxic activity. The different solvent soluble and mild activity herbal drug analgesic highest activity compared to standard drug, diclofenac sodium. Conclusion: Analgesic models based different parameter for studies bioactive compounds further for isolation and purification compounds.