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A procedure utilizing [TBA][P(SiCl3)2] as P source for the synthesis of phosphinecarboxamides is presented. The synthesis involves the reaction of [TBA][P(SiCl3)2] with isocyanates. These compounds act as highly effective reagents for the subsequent phosphination of isocyanates, leading to the formation of phosphine(triscarboxamides). This reaction proceeds swiftly under mild and straightforward conditions, making it suitable for a wide range of commercially available isocyanates. [ABSTRACT FROM AUTHOR]

Herein, we report a non‐metal strategy for cyclization reactions of 2‐vinylanilines with/without isonitriles to synthesize 2‐aminoquinoline and 3‐aryl‐1H‐indole derivatives. A series of 2‐aminoquinolines were afforded in good to excellent yields in a direct, facile, and efficient approach by Se‐catalyzed isocyanide insertion with 2‐vinylanilines under an air atmosphere. This reaction not only used low toxicity Se as the catalyst, isocyanobenzene substrates were compatible too compared to previous report. Meanwhile, an intramolecular cyclization of 2‐vinylanilines was developed to give 3‐aryl‐1H‐indoles in moderate to good yields by using SeO2 as oxidant. [ABSTRACT FROM AUTHOR]

We report a general protocol for the direct N-allylation of electron-poor N-heterocyclic amides and sulfonamides via an amide-aldehyde-alkene condensation reaction catalyzed by a Lewis acid. This process has a broad substrate scope with respect to N-heterocyclic amides including carbamates, carboxamides, and N-methylsulfonamides, and provides efficient access to a variety of allylamine derivatives in good yield with high regioselectivity. The utility of this method was also demonstrated by the rapid synthesis of Naftifine from N-methyl-1-naphthamide, paraformaldehyde, and styrene in one-pot. [ABSTRACT FROM AUTHOR]