Search

Objectives: The present study was conducted aiming to investigate lipid profile in patients with subclinical hypothyroidism as compared to age and sex matched controls. Methods: The study population consisted of total 80 subjects; 40 patients (cases) and 40 controls. Serum free tri-iodothyronine (fT3) and free thyroxine (fT4) were estimated by microplate competitive enzyme immunoassay, and thyroid stimulating hormone (TSH) measured by sandwich enzyme immunoassay. Lipid profile tests: Total Cholesterol, triglycerides, high density lipoprotein (HDL) cholesterol were estimated by enzymatic methods and low density lipoprotein cholesterol (LDL) was calculated by Friedewald’s formula. Results: Significant differences were observed between lipid parameters in case Vs controls: total cholesterol (4.9±1.1 Vs 4.3±1.0 mmol/L, P=0.03), triglycerides (1.9±0.7 Vs 1.6±0.6 mmol/L, P=0.02) and LDL cholesterol levels (3.5±1.1 Vs 2.9±0.9 mmol/L, P=0.02). In case Vs controls no significant differences were observed between HDL Cholesterol (1.1±0.2 Vs 1.1±0.7 mmol/L, P=0.07), VLDL (0.9±0.4 Vs 0.8±0.3 mmol/L, P=0.1) and Cholesterol/HDL ratio (4.48±1.40 Vs 4.06±0.89, P=0.118). Elevated TSH level were found in cases Vs controls (12.42±7.08 Vs 2.69±0.20 mIU/L, P=0.01) which was statistically significant. The subjects on control group were euthyroid, however increased fT3 (3.9±0.8Vs 4.6±0.8 pmol/L, P=