1. COGENT (COlorectal Cancer GENeTics): An International Consortium To Study The Role Of Polymorphic Variation On The Risk Of Colorectal Cancer.
- Author
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Tomlinson, I. P. M., Dunlop, M., Campbell, H., Zanke, B., Gallinger, S., Hudson, T., Koessler, T., Pharoah, P. D., Niittymäkix, I., Tuupanenx, S., Aaltonen, L. A., Hemminki, K., Lindblom, A., Försti, A., Sieber, O., Lipton, L., Wezel, T. van, Morreau, H., Wijnen, J. T., and Devilee, P.
- Subjects
COLON cancer risk factors ,FOLLOW-up studies (Medicine) ,HUMAN genetic variation ,GENE frequency ,HUMAN genome - Abstract
It is now recognised that a part of the inherited risk of colorectal cancer (CRC) can be explained by the co-inheritance of low-penetrance genetic variants. The accumulated experience to date in identifying these variants has served to highlight difficulties in conducting statistically and methodologically rigorous studies and follow-up analyses. The COGENT (COlorectal cancer GENeTics) consortium includes 20 research groups in Europe, Australia, the Americas, China and Japan. The overarching goal of COGENT is to identify and characterise low-penetrance susceptibility variants for CRC through association-based analyses. In this study, we review the rationale for identifying low-penetrance variants for CRC and our proposed strategy for establishing COGENT. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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