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Aim: Human behavior on eating is also partly regulated by a biological feed-back system. We attempted to correlate any results from dietary survey with single-nucleotide polymorphisms (SNPs) of β3-adrenergic receptor (BAR-3) and mitochondrial NADH dehydrogenase-2 (ND-2) genes. Methods: We studies 44 students (female 40, male 4) in our university with written informed consent. SNPs of BAR-3 (Trp64Arg) and ND-2 (Leu263Met) genes were detected by PCR-RFLP with genomic DNA prepared from buccal mucosa. A semiquantitative food-uptake frequency survey was conducted with a kit of "Jissun-houshi". Statistical multi-variant analysis was done with a software of SPSS. Body fat ratios were measured by conductivity. Results: Out of 30 items, only vitamin C-uptake was significantly higher in Met263-type of ND-2 gene than Leu263-type. As for SNP of BAR-3, Trp64-homozygote showed significantly higher animal protein ratio and higher cholesterol-uptake than Arg64-homozygote and heterozygotes. Conclusions: SNPs of BAR-3 and ND-2 genes may affect eating behavior in individual level besides biochemical process of signal transduction in cellular level. [ABSTRACT FROM AUTHOR]