1. Linking Computational Fluid Dynamics Modeling to Device-Induced Platelet Defects in Mechanically Assisted Circulation.
- Author
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Zhang J, Han D, Chen Z, Wang S, Sun W, Griffith BP, and Wu ZJ
- Abstract
Thrombotic and bleeding events are the most common hematologic complications in patients with mechanically assisted circulation and are closely related to device-induced platelet dysfunction. In this study, we sought to link computational fluid dynamics (CFD) modeling of blood pumps with device-induced platelet defects. Fresh human blood was circulated in circulatory loops with four pumps (CentriMag, HVAD, HeartMate II, and CH-VAD) operated under a total of six clinically representative conditions. Blood samples were collected and analyzed for glycoprotein (GP) IIb/IIIa activation and receptor shedding of GPIbα and GPVI. In parallel, CFD modeling was performed to characterize the blood flow in these pumps. Numerical indices of platelet defects were derived from CFD modeling incorporating previously derived power-law models under constant shear conditions. Numerical results were correlated with experimental results by regression analysis. The results suggested that a scalar shear stress of less than 75 Pa may have limited contribution to platelet damage. The platelet defect indices predicted by the CFD power-law models after excluding shear stress <75 Pa correlated excellently with experimentally measured indices. Although numerical prediction based on the power-law model cannot directly reproduce the experimental data. The power-law model has proven its effectiveness, especially for quantitative comparisons., Competing Interests: Disclosure: Z.J.W. and B.P.G. disclose financial interest in Abiomed-Breethe, Inc. and intellectual property for ECMO systems, blood pumps blood pumps, and relevant enabling technologies. Z.J.W. serves as a consultant to Daiichi Sankyo, Inc. and CH Biomedical USA, Inc. J.Z. discloses financial interest in intellectual property for ECMO systems and blood pumps. The other authors have no conflicts of interest to report., (Copyright © ASAIO 2024.)
- Published
- 2024
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