1. Analytical-physical profile of the novel macrolide antibiotic flurithromycin ethylsuccinate.
- Author
-
Colombo N, Depaoli A, Gobetti M, and Saorin MG
- Subjects
- Animals, Anti-Bacterial Agents pharmacokinetics, Anti-Bacterial Agents pharmacology, Bacteria drug effects, Biological Assay, Calorimetry, Differential Scanning, Chromatography, High Pressure Liquid, Chromatography, Thin Layer, Dogs, Erythromycin chemistry, Erythromycin pharmacokinetics, Erythromycin pharmacology, Humans, Magnetic Resonance Spectroscopy, Mass Spectrometry, Microbial Sensitivity Tests, Rats, Solubility, Spectrophotometry, Infrared, Spectrophotometry, Ultraviolet, Anti-Bacterial Agents chemistry, Erythromycin analogs & derivatives
- Abstract
Data are reported on the structural characterization of flurithromycin ethylsuccinate (FE, CAS 82730-23-2), a novel macrolide antibiotic. UV, IR, NMR and MS spectra confirmed the structure; in particular the presence of ketonic-hemiketalic equilibrium, already described for flurithromycin A, is supported by NMR and HPLC studies. Moreover physico-chemical properties and stability were studied; the product exhibits a good stability at solid state, whereas degradation products are present both in acidic and basic solution. Microbiological activity and principal pharmaceutical features were carried out.
- Published
- 1994