1. Synthesis and antimicrobial activity of dihydrofurobenzoxazolin-2(3H)-ones and their derivatives.
- Author
-
Bhalerao UT, Gawali BB, and Annapurna J
- Subjects
- Anti-Bacterial Agents, Anti-Infective Agents pharmacology, Bacteria drug effects, Benzoxazoles pharmacology, Fungi drug effects, Furans pharmacology, Gram-Negative Bacteria drug effects, Gram-Positive Bacteria drug effects, Magnetic Resonance Spectroscopy, Microbial Sensitivity Tests, Spectrophotometry, Infrared, Anti-Infective Agents chemical synthesis, Benzoxazoles chemical synthesis, Furans chemical synthesis
- Abstract
A series of dihydrofurobenzoxazolin-2(3H)-ones and their derivatives were synthesized. The structures of the compounds have been elucidated by IR, mass, 1H-NMR spectra and elementary analysis. The in vitro activity of these compounds was investigated against Gram-positive and Gram-negative bacteria and also against Candida albicans. 7,7-Dimethyl-7,8-dihydro-furo[2,3-g]benzoxazolin-2(3H)-one (compound 2) proved to be more potent than compound 1. Compound 3 also showed significant activity against all the microbes tested. Compounds 4 and 5 were more effective against Gram-positive bacteria than Gram-negative bacteria but inactive against C. albicans.
- Published
- 1994