1. Polyurethane/hydroxypropyl cellulose electrospun nanofiber mats as potential transdermal drug delivery system: characterization studies and in vitro assays.
- Author
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Gencturk A, Kahraman E, Güngör S, Özhan G, Özsoy Y, and Sarac AS
- Subjects
- Animals, Cell Survival drug effects, Cellulose chemistry, Donepezil, Drug Compounding, Drug Liberation, Electrochemical Techniques, Indans chemistry, Indans pharmacology, Kinetics, Membranes, Artificial, Mice, Molecular Mimicry, NIH 3T3 Cells, Nanofibers ultrastructure, Nootropic Agents chemistry, Nootropic Agents pharmacology, Permeability, Piperidines chemistry, Piperidines pharmacology, Skin drug effects, Skin metabolism, Cellulose analogs & derivatives, Drug Carriers, Indans metabolism, Nanofibers chemistry, Nootropic Agents metabolism, Piperidines metabolism, Polyurethanes chemistry
- Abstract
Donepezil hydrochloride containing polyurethane/hydroxypropyl cellulose (PU/HPC) nanofibers were prepared by the electrospinning for transdermal drug delivery. PU/HPC nanofibers were characterized with SEM, DSC, and Pascal mercury porosimetry. Drug-excipient interaction was studied by ATR-FTIR. In vitro release of PU/HPC nanofiber mat (10:2:1) exhibited Korsmeyer-Peppas release kinetics controlled by the diffusion of drug. In vitro permeation studies across skin resembling synthetic membrane demonstrated the flux of model drug. The in vitro cytotoxicity data obtained via MTT assay indicated that PU/HPC nanofiber mat could be well tolerated by the skin and the components was not irritant for the skin.
- Published
- 2017
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