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19 results on '"Mariette , Xavier"'

5. Link between traditional cardiovascular risk factors and inflammation in patients with early arthritis: Results from a French Multicenter Cohort

Author

Boyer, Jean, Bongard, Vanina, Cantagrel, Alain, Jamard, Bénédicte, Gottenberg, Jacques-Eric, Mariette, Xavier, Davignon, Jean, Ferrières, Jean, Ruidavets, Jean, Dallongeville, Jean, Arveiler, Dominique, Cambon-Thomsen, Anne, Constantin, Arnaud, Saraux, Alain, CHU Toulouse [Toulouse], Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Hôpital de Hautepierre [Strasbourg], Hôpital Bicêtre, Centre de Physiopathologie Toulouse Purpan ex IFR 30 et IFR 150 (CPTP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Biomolécules et inflammation pulmonaire, Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé, Progression tumorale et microenvironnement. Approches translationnelles et épidémiologie, Université de Strasbourg (UNISTRA)-CHU Strasbourg-Les Hôpitaux Universitaires de Strasbourg (HUS)-Institut Régional du Cancer-Centre Paul Strauss : Centre Régional de Lutte contre le Cancer (CRLCC), Centre d'Investigation Clinique INSERM 1412 (CIC 1412 - BREST), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Lymphocyte B et Auto-immunité (LBAI), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), CHRU Brest - Service de Rhumatologie (CHU - BREST - Rhumato), An unrestricted grant from Merck Sharp & Dohme (MSD)was allocated for the first 5 years. Two additional grantsfrom INSERM were obtained to support part of the biologicdatabase. The ESPOIR cohort study was also supported bythe French Society of Rheumatology, Abbott, Wyeth-Pfizer,and Roche., We thank Pascale Roux‐Lombard and Jean‐Michel Dayer, Division of Immunology and Allergy, University Hospital of Geneva, Geneva, Switzerland, for quantification of serum IL‐6, and Ms Nathalie Rincheval, Laboratoire Biostatistique et Epidémiologie, Institut Universitaire de Recherche Clinique, Montpellier, France, for data management and technical support. We also wish to thank all of the investigators who recruited and followed the patients (F. Berenbaum, Paris‐Saint Antoine, M.‐C. Boissier, Paris‐Bobigny, B. Combe, Montpellier, M. Dougados, Paris‐Cochin, P. Fardelonne, P. Boumier, Amiens, B. Fautrel, P. Bourgeois, Paris‐La Pitié, R.‐M. Flipo, Lille, Ph. Goupille, Tours, F. Liote, Paris‐Lariboisière, X. Le Loet, O. Vittecoq, Rouen, O. Meyer, Paris‐Bichat, A. Saraux, Brest, Th. Schaeverbeke, Bordeaux, J. Sibilia, Strasbourg, France)., Centre de Physiopathologie Toulouse Purpan (CPTP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Régional du Cancer-Université de Strasbourg (UNISTRA)-CHU Strasbourg-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre Paul Strauss : Centre Régional de Lutte contre le Cancer (CRLCC), Centre d'Investigation Clinique (CIC - Brest), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Blood Glucose, Male, MESH: Inflammation, [SDV]Life Sciences [q-bio], Arthritis, Blood Pressure, 030204 cardiovascular system & hematology, Systemic inflammation, Gastroenterology, Cohort Studies, chemistry.chemical_compound, 0302 clinical medicine, Risk Factors, MESH: Risk Factors, MESH: Early Diagnosis, MESH: Incidence, MESH: Cohort Studies, MESH: Aged, MESH: Middle Aged, Incidence, MESH: Blood Pressure, Middle Aged, MESH: Case-Control Studies, 3. Good health, Pulse pressure, C-Reactive Protein, Cardiovascular Diseases, Cohort, Female, lipids (amino acids, peptides, and proteins), France, MESH: Cholesterol, HDL, medicine.symptom, MESH: Cholesterol, LDL, Adult, MESH: Triglycerides, medicine.medical_specialty, MESH: Arthritis, 03 medical and health sciences, Rheumatology, Internal medicine, MESH: C-Reactive Protein, medicine, Humans, Risk factor, Triglycerides, Aged, Inflammation, 030203 arthritis & rheumatology, MESH: Humans, Interleukin-6, business.industry, Cholesterol, Cholesterol, HDL, MESH: Cardiovascular Diseases, MESH: Adult, Cholesterol, LDL, medicine.disease, MESH: Interleukin-6, MESH: Male, MESH: France, Early Diagnosis, Blood pressure, Endocrinology, chemistry, Case-Control Studies, MESH: Blood Glucose, business, MESH: Female, Lipoprotein
Abstract

Objective To compare the characteristics of traditional cardiovascular risk factors for untreated patients with early arthritis (EA) and healthy subjects, and to look for a link between cardiovascular risk factors and inflammation in EA patients. Methods This multicenter case–control study enrolled 607 patients with EA (ESPOIR cohort) and 1,821 age- and sex-matched controls (World Health Organization MONICA survey). Lipid levels, blood pressure, glucose levels, and exposure to smoking were characterized in patients and controls. Systemic inflammation was quantified in EA patients. Traditional cardiovascular risk factor characteristics were compared between patients with EA and controls. The link between cardiovascular risk factors and inflammation was assessed in EA patients. Results Mean ± SEM total cholesterol (2.14 ± 0.022 versus 2.34 ± 0.017 gm/liter; P < 0.001), high-density lipoprotein (HDL) cholesterol (0.60 ± 0.011 versus 0.63 ± 0.007 gm/liter; P = 0.020), and low-density lipoprotein (LDL) cholesterol (1.28 ± 0.025 versus 1.51 ± 0.016 gm/liter; P < 0.001) were lower in EA patients than in controls. Triglycerides, triglycerides/HDL ratio, and pulse pressure were higher in patients with EA. Diastolic blood pressure and glucose levels were lower in EA patients. Former or current smokers were more frequent in patients with EA. Total and HDL cholesterol levels were negatively associated with C-reactive protein or serum interleukin-6 levels. Conclusion Total, HDL, and LDL cholesterol, triglycerides, diastolic blood pressure, pulse pressure, glucose, and triglycerides/HDL ratio differ between patients with EA and controls. Some of these risk factors appear to be linked to systemic inflammation. Such initial differences could modulate the risk of cardiovascular events later in the course of arthritis.

Published
2012
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6. Severe Health‐Related Quality of Life Impairment in Active Primary Sjögren's Syndrome and Patient‐Reported Outcomes: Data From a Large Therapeutic Trial

Author

Cornec, Divi, primary, Devauchelle‐Pensec, Valérie, additional, Mariette, Xavier, additional, Jousse‐Joulin, Sandrine, additional, Berthelot, Jean‐Marie, additional, Perdriger, Aleth, additional, Puéchal, Xavier, additional, Le Guern, Véronique, additional, Sibilia, Jean, additional, Gottenberg, Jacques‐Eric, additional, Chiche, Laurent, additional, Hachulla, Eric, additional, Yves Hatron, Pierre, additional, Goeb, Vincent, additional, Hayem, Gilles, additional, Morel, Jacques, additional, Zarnitsky, Charles, additional, Dubost, Jean Jacques, additional, Saliou, Philippe, additional, Pers, Jacques Olivier, additional, Seror, Raphaèle, additional, and Saraux, Alain, additional

Published
2017
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7. Evaluation of Serum Interleukin-6 Level as a Surrogate Marker of Synovial Inflammation and as a Factor of Structural Progression in Early Rheumatoid Arthritis: Results From a French National Multicenter Cohort

Author

Baillet, Athan, primary, Gossec, Laure, additional, Paternotte, Simon, additional, Etcheto, Adrien, additional, Combe, Bernard, additional, Meyer, Olivier, additional, Mariette, Xavier, additional, Gottenberg, Jacques-Eric, additional, and Dougados, Maxime, additional

Published
2015
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8. Efficacy and Safety of Rituximab in Elderly Patients With Rheumatoid Arthritis Enrolled in a French Society of Rheumatology Registry

Author

Payet, Sarah, primary, Soubrier, Martin, additional, Perrodeau, Elodie, additional, Bardin, Thomas, additional, Cantagrel, Alain, additional, Combe, Bernard, additional, Dougados, Maxime, additional, Flipo, René‐Marc, additional, Le Loët, Xavier, additional, Shaeverbeke, Thierry, additional, Ravaud, Philippe, additional, Gottenberg, Jacques‐Eric, additional, and Mariette, Xavier, additional

Published
2014
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9. Error in the Abstract in the Article by Maldini et al (Arthritis Care Res [Hoboken], March 2014)

Author

Maldini, Carla, primary, Seror, Raphaèle, additional, Fain, Olivier, additional, Dhote, Robin, additional, Amoura, Zahir, additional, De Bandt, Michel, additional, Delassus, Jean-Luc, additional, Falgarone, Géraldine, additional, Guillevin, Loïc, additional, Le Guern, Véronique, additional, Lhote, François, additional, Meyer, Olivier, additional, Ramanoelina, Jacky, additional, Sacré, Karim, additional, Uzunhan, Yurdagul, additional, Leroux, Jean-Louis, additional, Mariette, Xavier, additional, and Mahr, Alfred, additional

Published
2014
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10. Epidemiology of Primary Sjögren's Syndrome in a French Multiracial/Multiethnic Area

Author

Maldini, Carla, primary, Seror, Raphaèle, additional, Fain, Olivier, additional, Dhote, Robin, additional, Amoura, Zahir, additional, De Bandt, Michel, additional, Delassus, Jean-Luc, additional, Falgarone, Géraldine, additional, Guillevin, Loïc, additional, Le Guern, Véronique, additional, Lhote, François, additional, Meyer, Olivier, additional, Ramanoelina, Jacky, additional, Sacré, Karim, additional, Uzunhan, Yurdagul, additional, Leroux, Jean-Louis, additional, Mariette, Xavier, additional, and Mahr, Alfred, additional

Published
2014
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11. Usefulness of 2‐[18F]‐fluoro‐2‐deoxy‐d‐glucose–Positron Emission Tomography/Computed Tomography for Staging and Evaluation of Treatment Response in IgG4‐Related Disease: A Retrospective Multicenter Study

Author

Ebbo, Mikael, primary, Grados, Aurélie, additional, Guedj, Eric, additional, Gobert, Delphine, additional, Colavolpe, Cécile, additional, Zaidan, Mohamad, additional, Masseau, Agathe, additional, Bernard, Fanny, additional, Berthelot, Jean‐Marie, additional, Morel, Nathalie, additional, Lifermann, François, additional, Palat, Sylvain, additional, Haroche, Julien, additional, Mariette, Xavier, additional, Godeau, Bertrand, additional, Bernit, Emmanuelle, additional, Costedoat‐Chalumeau, Nathalie, additional, Papo, Thomas, additional, Hamidou, Mohamed, additional, Harlé, Jean‐Robert, additional, and Schleinitz, Nicolas, additional

Published
2013
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13. Potential Classification Criteria for Rheumatoid Arthritis After Two Years: Results From a French Multicenter Cohort

Author

Saraux, Alain, primary, Tobón, Gabriel J., additional, Benhamou, Mathilde, additional, Devauchelle-Pensec, Valérie, additional, Dougados, Maxime, additional, Mariette, Xavier, additional, Berenbaum, Francis, additional, Chiocchia, Gilles, additional, Rat, Anne-Christine, additional, Schaeverbeke, Thierry, additional, Rincheval, Nathalie, additional, Meyer, Olivier, additional, Fautrel, Bruno, additional, and Combe, Bernard, additional

Published
2013
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15. Usefulness of 2-[(18) F]-fluoro-2-deoxy-d-glucose-Positron Emission Tomography/Computed Tomography for Staging and Evaluation of Treatment Response in IgG4-Related Disease: A Retrospective Multicenter Study.

Author

Ebbo, Mikael, Grados, Aurélie, Guedj, Eric, Gobert, Delphine, Colavolpe, Cécile, Zaidan, Mohamad, Masseau, Agathe, Bernard, Fanny, Berthelot, Jean-Marie, Morel, Nathalie, Lifermann, François, Palat, Sylvain, Haroche, Julien, Mariette, Xavier, Godeau, Bertrand, Bernit, Emmanuelle, Costedoat-Chalumeau, Nathalie, Papo, Thomas, Hamidou, Mohamed, and Harlé, Jean-Robert

Published
2014
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16. Usefulness of 2-[18F]-fluoro-2-deoxy- d-glucose-Positron Emission Tomography/Computed Tomography for Staging and Evaluation of Treatment Response in IgG4-Related Disease: A Retrospective Multicenter Study.

Author

Ebbo, Mikael, Grados, Aurélie, Guedj, Eric, Gobert, Delphine, Colavolpe, Cécile, Zaidan, Mohamad, Masseau, Agathe, Bernard, Fanny, Berthelot, Jean-Marie, Morel, Nathalie, Lifermann, François, Palat, Sylvain, Haroche, Julien, Mariette, Xavier, Godeau, Bertrand, Bernit, Emmanuelle, Costedoat-Chalumeau, Nathalie, Papo, Thomas, Hamidou, Mohamed, and Harlé, Jean-Robert

Abstract

Objective To evaluate the usefulness of 2-[18F]-fluoro-2-deoxy- d-glucose-positron emission tomography/computed tomography (FDG-PET/CT) in IgG4-related disease (IgG4-RD) for the staging of the disease and the followup under treatment. Methods All patients included in the French IgG4-RD registry who underwent ≥1 FDG-PET/CT scan were included in the study. Clinical, biologic, pathologic, radiologic, and FDG-PET/CT qualitative and quantitative findings were retrospectively collected and analyzed. Results Twenty-one patients were included in the study and 46 FDG-PET/CT examinations were evaluated. At either diagnosis or relapse, all evaluated patients presented abnormal 18F-FDG uptake in typical IgG4-RD localizations. In most cases, FDG-PET/CT was more sensitive than conventional imaging to detect organ involvement, especially in arteries, salivary glands, and lymph nodes. In few cases (small-sized lesions and brain or kidney contiguous lesions), false-negative results were noted. Evaluation before and after treatment showed in most cases a good correlation of FDG-PET/CT results with treatment response and disease activity. Conclusion This large retrospective study shows that FDG-PET/CT imaging is useful for the staging of IgG4-RD. Moreover, FDG-PET/CT is useful to assess the response to treatment during followup. [ABSTRACT FROM AUTHOR]

Published
2014
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