1. Neuropathologic findings in multi-infarct dementia associated with anticardiolipin antibody. Evidence for endothelial injury as the primary event.
- Author
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Westerman EM, Miles JM, Backonja M, and Sundstrom WR
- Subjects
- Antiphospholipid Syndrome complications, Antiphospholipid Syndrome immunology, Antiphospholipid Syndrome pathology, Arterioles pathology, Biopsy, Brain blood supply, Dementia, Multi-Infarct etiology, Humans, Hyperplasia, Male, Middle Aged, Thrombosis etiology, Thrombosis pathology, Antibodies, Anticardiolipin immunology, Brain pathology, Dementia, Multi-Infarct pathology, Endothelium, Vascular pathology
- Abstract
Objective: There are few reports describing histopathologic changes associated with the antiphospholipid antibody syndrome. We describe a patient with multi-infarct dementia and antiphospholipid antibody syndrome, in whom a brain biopsy was performed., Methods: Biopsy material from the left frontal cortex, including meninges, cortex, and underlying subcortical white matter, was investigated. Microscopic examination and special staining were performed., Results: Microscopic examination showed lumenal occlusion by thrombi, and marked endothelial hyperplasia of small meningeal and cortical arterioles., Conclusion: These findings suggest that the pathogenesis of this cerebral vasculopathy is noninflammatory and is associated with reactive endothelial hyperplasia and thrombosis of small arterioles.
- Published
- 1992
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