1. Association Between Severe Nonadherence to Hydroxychloroquine and Systemic Lupus Erythematosus Flares, Damage, and Mortality in 660 Patients From the SLICC Inception Cohort.
- Author
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Nguyen, Yann, Blanchet, Benoît, Urowitz, Murray, Hanly, John, Gordon, Caroline, Bae, Sang-Cheol, Romero-Diaz, Juanita, Sanchez-Guerrero, Jorge, Clarke, Ann, Bernatsky, Sasha, Wallace, Daniel, Isenberg, David, Rahman, Anisur, Merrill, Joan, Fortin, Paul, Gladman, Dafna, Bruce, Ian, Petri, Michelle, Ginzler, Ellen, Dooley, Mary, Ramsey-Goldman, Rosalind, Manzi, Susan, Jönsen, Andreas, Alarcón, Graciela, Van Vollenhoven, Ronald, Aranow, Cynthia, Le Guern, Véronique, Mackay, Meggan, Ruiz-Irastorza, Guillermo, Lim, S, Inanc, Murat, Jacobsen, Søren, Peschken, Christine, Kamen, Diane, Askanase, Anca, Buyon, Jill, Costedoat-Chalumeau, Nathalie, and Kalunian, Kenneth
- Subjects
Humans ,Female ,Male ,Hydroxychloroquine ,Lupus Erythematosus ,Systemic ,Prednisone ,Immunosuppressive Agents ,Proportional Hazards Models - Abstract
OBJECTIVE: The goals of this study were to assess the associations of severe nonadherence to hydroxychloroquine (HCQ), objectively assessed by HCQ serum levels, and risks of systemic lupus erythematosus (SLE) flares, damage, and mortality rates over five years of follow-up. METHODS: The Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort is an international multicenter initiative (33 centers throughout 11 countries). The serum of patients prescribed HCQ for at least three months at enrollment were analyzed. Severe nonadherence was defined by a serum HCQ level
- Published
- 2023