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Start Over Author "Yammani, Raghunatha R." Journal arthritis & rheumatism

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1 results on '"Yammani, Raghunatha R."'

1. Increased Expression of the Akt/PKB Inhibitor TRB3 in Osteoarthritic Chondrocytes Inhibits Insulin-like Growth Factor 1-Mediated Cell Survival and Proteoglycan Synthesis.

Author

Cravero, John D., Carlson, Cathy S., Hee-Jeong Im, Yammani, Raghunatha R., David Long, and Loeser, Richard F.

Subjects
*GENE expression, *OSTEOARTHRITIS, *GROWTH factors, *MESSENGER RNA, *CARTILAGE cells, *ENDOPLASMIC reticulum, *PROTEOGLYCANS
Abstract

The article discussess the study which determines the increased expression of the Akt/PKB inhibitor TRB3 in osteoarthritic chondrocytes inhibits insulin-like growth factor 1-mediated cell survival and proteoglycan synthesis. The study indicates the role of TRB3 in the increased cell death and reduced response to insulin-like growth factor observed in osteoarthritis cartilage. It shows that TRB3 messenger RNA detects normal human chondrocytes from normal cartilage induced endoplasmic reticulum.

Published
2009
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