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The article presents a study which examined the binding of the granulin-epithelin precursor (GEP) to metalloproteinase ADAMTS-7 and ADAMTS-12 and its inhibitory function in the degradation of cartilage oligomeric matrix protein. According to the authors, GEP directly bound to ADAMTS-7 and ADAMTS-12 in vitro and in chondrocytes and each unit of granulin in GEP mediated their interactions. They indicate the important role of ADAMTS-7/ADAMTS-12 in inhibiting the degradation of joint cartilage in arthritis.