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20 results on '"Meani, A."'

3. P4.20 SHORT-TERM EFFECT OF ANTI-VEGF DRUGS ON HEART AND VESSELS

Author

F. Cesana, C. Colombo, C. Valsecchi, M. Stucchi, P. Vallerio, A. Cereda, P. Meani, R. Ricotta, S. Siena, and C. Giannattasio

Subjects
Specialties of internal medicine, RC581-951, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Objectives: Drugs opposing the effect of vascular endothelial growth factor (anti-VEGF) inhibit angiogenesis slowing down and eventually stopping solid tumors growth. Nevertheless these drugs can cause hypertension (that seems to be correlated with cancer outcome) and cardiac dysfunction. We hypnotize there is a correlation between the early stiffening of cardiovascular system and the drug effectiveness. For this purpose we analyzed the short term changes in cardiovascular structure and function in patients treated with antiVEGF drugs. Methods: We enrolled 20 patients suffering from metastatic cancer (17 renal, 2 thyroid and 1 GIST), age 64±11 years (mean±SD). We measured blood pressures (BPs), cardiac and vascular parameters at baseline (B) and after two weeks of treatment (T1) (transthoracic echocardiography with 2D strain evaluation, cf-PWV, Aix). Results: At B our population showed normal BPs (mean±SD:121±17/69±9.5mmHg) and systolic function (EF: 59%,). Global longitudinal strain (GLS) was −21±3%, cf PWV was 12.1±3.3m/sec and Aix was 0.24±0,08%. At T1 we observed a significant increase in BPs (137±16/83±10mmHg, p

Published
2013
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4. P1.12 PREDICTIVE COMBINED ROLE OF CALCIUM SCORE AND CAROTIDIMT IN CORONARY ARTERY DISEASE

Author

P. Meani, F. Cesana, A. Fallanca, C. Valsecchi, F. Musca, P. Campadello, F. Soriano, P. Faggiano, F. Rigo, A. Moreo, M.L. Muiesan, A. Paini, G.F. Mureddu, N. Gaibazzi, and C. Giannattasio

Subjects
Specialties of internal medicine, RC581-951, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Objectives: up to date the assessment of coronary artery disease (CAD) risk is based mainly on the presence of CV risk factors. However, many markers of subclinical atherosclerosis has been demonstrated as powerful predictors of CV events. Aim of our study was to evaluate if non invasive US parameters, such as carotid properties and heart calcifications, are able to add information to the prediction of CAD. Methods: In 405 in-patients with a clinical indication (overt angina and/or positive exercise test) for coronary angiography (CA), we measured blood pressures (BP), carotid intima-media thickness (IMT), local PWV and distensibility and quantified cardiac calcification by means of Calcium Score (CaS). After CA we divided the group in G1 (N=240) (patients with at least one coronary stenosis >50%), and G0 (N=165) (unaffected coronaries). Results: G0 and G1 patients differed in age (67±10 vs 64±11yrs,p=0,01), but not in BMI (26±3.5 vs 28±16 kg/m2,p=0,03); G1 had higher BP (130±21/74±10 vs 136±18/77±11mmHg, p

Published
2013
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11. P7.2 IDENTIFICATION OF VASCULAR AND CIRCULATING BIOMARKERS TO PREDICT OUTCOME IN PATIENTS AFFECTED BY SEPTIC SHOCK

Author

F. Musca, L. Bonacchini, O. Belli, Paolo Meani, Miriam Stucchi, M. Alloni, M. Molteni, Cristina Giannattasio, P. Vallerio, G. Monti, F. Panzeri, L. Frigerio, M. Cazzaniga, A. De Gasperi, and Roberto Fumagalli

Subjects
Oncology, medicine.medical_specialty, Septic shock, business.industry, Specialties of internal medicine, General Medicine, medicine.disease, Circulating biomarkers, RC581-951, Internal medicine, RC666-701, medicine, Diseases of the circulatory (Cardiovascular) system, In patient, Identification (biology), business
Published
2014

12. 4.1 PULSE WAVE VELOCITY CHANGES OVER A FOUR YEARS FOLLOW UP: SYNERGIC EFFECTS OF DIABETES AND HYPERTENSION

Author

M.A. Moreo, V.M. Varrenti, R.D. Ribecca, G.C. Giannattasio, G.L. Giupponi, M.P. Meani, C.F. Cesana, S.F. Soffici, M.G. Mancia, C.F. Castagna, S.M. Stucchi, F.R. Facchetti, B.M. Baroni, and N.S. Nava

Subjects
medicine.medical_specialty, lcsh:Diseases of the circulatory (Cardiovascular) system, lcsh:Specialties of internal medicine, business.industry, General Medicine, medicine.disease, lcsh:RC581-951, lcsh:RC666-701, Diabetes mellitus, Internal medicine, medicine, Cardiology, business, Pulse wave velocity
Published
2012

13. P5.9 LACK OF RECOVERY IN NOCTURNAL DECLINE OF HEART RATE AND BLOOD PRESSURE AFTER HEART TRASPLANTATION

Author

L. Bonacchini, Siegfried Wassertheurer, Paolo Meani, M. Frigerio, Gianfranco Parati, Marisa Varrenti, V. Riva, Alessandro Maloberti, L. Giupponi, Cristina Giannattasio, and F. Turazza

Subjects
medicine.medical_specialty, business.industry, Specialties of internal medicine, General Medicine, Nocturnal, Blood pressure, RC581-951, RC666-701, Internal medicine, Heart rate, medicine, Cardiology, Diseases of the circulatory (Cardiovascular) system, business
Published
2014
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14. P4.20 SHORT-TERM EFFECT OF ANTI-VEGF DRUGS ON HEART AND VESSELS

Author

Paolo Meani, Riccardo Ricotta, Francesca Cesana, C. Valsecchi, Salvatore Siena, Miriam Stucchi, P. Vallerio, C. Colombo, Cristina Giannattasio, and A. Cereda

Subjects
Anti vegf, RC581-951, business.industry, RC666-701, Specialties of internal medicine, Diseases of the circulatory (Cardiovascular) system, Medicine, Term effect, General Medicine, Pharmacology, business
Abstract

Objectives: Drugs opposing the effect of vascular endothelial growth factor (anti-VEGF) inhibit angiogenesis slowing down and eventually stopping solid tumors growth. Nevertheless these drugs can cause hypertension (that seems to be correlated with cancer outcome) and cardiac dysfunction. We hypnotize there is a correlation between the early stiffening of cardiovascular system and the drug effectiveness. For this purpose we analyzed the short term changes in cardiovascular structure and function in patients treated with antiVEGF drugs. Methods: We enrolled 20 patients suffering from metastatic cancer (17 renal, 2 thyroid and 1 GIST), age 64±11 years (mean±SD). We measured blood pressures (BPs), cardiac and vascular parameters at baseline (B) and after two weeks of treatment (T1) (transthoracic echocardiography with 2D strain evaluation, cf-PWV, Aix). Results: At B our population showed normal BPs (mean±SD:121±17/69±9.5mmHg) and systolic function (EF: 59%,). Global longitudinal strain (GLS) was −21±3%, cf PWV was 12.1±3.3m/sec and Aix was 0.24±0,08%. At T1 we observed a significant increase in BPs (137±16/83±10mmHg, p

Published
2013
Full Text
View/download PDF

15. P1.12 PREDICTIVE COMBINED ROLE OF CALCIUM SCORE AND CAROTIDIMT IN CORONARY ARTERY DISEASE

Author

Pompilio Faggiano, Paolo Meani, F. Musca, Francesca Cesana, C. Valsecchi, G.F. Mureddu, M.L. Muiesan, Nicola Gaibazzi, Anna Paini, P. Campadello, Francesco Soriano, F. Rigo, Antonella Moreo, Cristina Giannattasio, and A. Fallanca

Subjects
medicine.medical_specialty, Framingham Risk Score, business.industry, Specialties of internal medicine, General Medicine, medicine.disease, Coronary artery disease, RC581-951, RC666-701, Internal medicine, Cardiology, Diseases of the circulatory (Cardiovascular) system, Medicine, cardiovascular diseases, business, Calcium score
Abstract

Objectives: up to date the assessment of coronary artery disease (CAD) risk is based mainly on the presence of CV risk factors. However, many markers of subclinical atherosclerosis has been demonstrated as powerful predictors of CV events. Aim of our study was to evaluate if non invasive US parameters, such as carotid properties and heart calcifications, are able to add information to the prediction of CAD. Methods: In 405 in-patients with a clinical indication (overt angina and/or positive exercise test) for coronary angiography (CA), we measured blood pressures (BP), carotid intima-media thickness (IMT), local PWV and distensibility and quantified cardiac calcification by means of Calcium Score (CaS). After CA we divided the group in G1 (N=240) (patients with at least one coronary stenosis >50%), and G0 (N=165) (unaffected coronaries). Results: G0 and G1 patients differed in age (67±10 vs 64±11yrs,p=0,01), but not in BMI (26±3.5 vs 28±16 kg/m2,p=0,03); G1 had higher BP (130±21/74±10 vs 136±18/77±11mmHg, p

Published
2013
Full Text
View/download PDF

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