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Your search keyword '"thermal tests"' showing total 3 results
Start Over Descriptor "thermal tests" Journal arquivos de neuro-psiquiatria
3 results on '"thermal tests"'

1. Possible analgesic effect of vigabatrin in animal experimental chronic neuropathic pain

Author

NILZA D. ALVES, CARLOS M. DE CASTRO-COSTA, ALBA M. DE CARVALHO, FRANKLIN J. C. SANTOS, and DELANO G. SILVEIRA

Subjects
vigabatrin, experimental, neuropathic pain, scratching behavior, thermal tests, Wistar rats, analgesia, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Since anticonvulsants have been used for treating neuralgias, an interest has arisen to experimentally test vigabatrin for its gabaergic mechanism of action. For this, 41 Wistar rats were used, and in 25 of them a constrictive sciatic neuropathy was induced (Bennet & Xie model). For testing pain symptoms, spontaneous (scratching) and evoked behaviors to noxious (46o C) and non-noxious (40o C) thermal stimuli were quantified. Moreover, a comparative pharmacological study of vigabatrin with other analgesic anticonvulsant drugs was also performed. The results showed a possible dose-dependent analgesic effect of vigabatrin (gamma-vinyl-GABA) on experimental neuropathic pain, as shown by the significant (p

Published
1999
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2. Possível efeito analgésico da vigabatrina na dor neuropática crônica experimental animal

Author

Alba Maria Pinho de Carvalho, Franklin J. C. Santos, Nilza Dutra Alves, Delano G. Silveira, and Carlos Maurício de Castro-Costa

Subjects
Phenytoin, genetic structures, experimental, Analgesic, Neurosciences. Biological psychiatry. Neuropsychiatry, Vigabatrin, thermal tests, scratching behavior, Animals, Medicine, Rats, Wistar, comportamento de coçar-se, neuropathic pain, Analgesics, Valproic Acid, business.industry, dor neuropática, analgesia, Carbamazepine, Scratching, testes térmicos, Rats, ratos Wistar, nervous system diseases, Wistar rats, vigabatrina, Neurology, Opioid, Anesthesia, Chronic Disease, Neuropathic pain, Neuralgia, Anticonvulsants, Neurology (clinical), business, vigabatrin, medicine.drug, RC321-571
Abstract

Since anticonvulsants have been used for treating neuralgias, an interest has arisen to experimentally test vigabatrin for its gabaergic mechanism of action. For this, 41 Wistar rats were used, and in 25 of them a constrictive sciatic neuropathy was induced (Bennet & Xie model). For testing pain symptoms, spontaneous (scratching) and evoked behaviors to noxious (46o C) and non-noxious (40o C) thermal stimuli were quantified. Moreover, a comparative pharmacological study of vigabatrin with other analgesic anticonvulsant drugs was also performed. The results showed a possible dose-dependent analgesic effect of vigabatrin (gamma-vinyl-GABA) on experimental neuropathic pain, as shown by the significant (p

Published
1999

3. Possible analgesic effect of vigabatrin in animal experimental chronic neuropathic pain

Author

ALVES NILZA D., CASTRO-COSTA CARLOS M. DE, CARVALHO ALBA M. DE, SANTOS FRANKLIN J. C., and SILVEIRA DELANO G.

Subjects
neuropathic pain, Wistar rats, genetic structures, experimental, thermal tests, scratching behavior, analgesia, vigabatrin, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, nervous system diseases, lcsh:RC321-571
Abstract

Since anticonvulsants have been used for treating neuralgias, an interest has arisen to experimentally test vigabatrin for its gabaergic mechanism of action. For this, 41 Wistar rats were used, and in 25 of them a constrictive sciatic neuropathy was induced (Bennet & Xie model). For testing pain symptoms, spontaneous (scratching) and evoked behaviors to noxious (46o C) and non-noxious (40o C) thermal stimuli were quantified. Moreover, a comparative pharmacological study of vigabatrin with other analgesic anticonvulsant drugs was also performed. The results showed a possible dose-dependent analgesic effect of vigabatrin (gamma-vinyl-GABA) on experimental neuropathic pain, as shown by the significant (p

Published
1999

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