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Start Over Descriptor "Plexo submucoso" Journal arquivos de neuro-psiquiatria
4 results on '"Plexo submucoso"'

1. Morphoquantitative study of the submucous plexus (of Meissner) of the jejunum-ileum of young and old guinea pigs

Author

Marcelo César Zanesco and Romeu Rodrigues de Souza

Subjects
envelhecimento, morfometria, plexo submucoso, jejuno-íleo, cobaia, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

OBJECTIVE: To study the aging of submucous plexus of the small intestine (jejunum-ileum) of the guinea pigs from the quantitative, structural and ultrastructural perspective. METHOD: Chemical preparations of membrane of the jejunum-ileum of old and young animals with the use of light and electronic microscope. RESULTS: The ganglia of young animals presented between 1 and 56 neurons and the old animals presented from 1 to 30 neurons. The mean density of the ganglia by cm² in the young jejunum-ileum was of 551±36.89 and in the old one 413±11.86. The density of the neurons was 5011±291.11 neurons/cm² average in young animals and 2918±120.70 neurons/cm² in the old ones. The size of the neurons varied in both age groups. The collagen fibers in the ganglia of old animals they were condensed. Degenerated mitochondrias in the interior of the cell were frequent in the old animals. CONCLUSION: In submucous plexus of the jejunum-ileum there is a loss of 38% of the neurons with aging.

Published
2011
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2. Morphoquantitative study of the submucous plexus (of Meissner) of the jejunum-ileum of young and old guinea pigs.

Author

Zanesco, Marcelo César and de Souza, Romeu Rodrigues

Abstract

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Published
2011
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3. Effect of acetyl-L-carnitine on Vip-ergic neurons in jejunum submucous plexus of diabetic rats Efeito da acetil-L-carnitina sobre neurônios Vip-érgicos do plexo submucoso do jejuno de ratos diabéticos

Author

Marli Aparecida Defani, Jacqueline Nelisis Zanoni, Maria Raquel Marçal Natali, Roberto Barbosa Bazotte, and Marcílio Hubner de Miranda-Neto

Subjects
VIP, submucous plexus, diabetes, rato, acetil-L-carnitina, rat, jejuno, acetyl-L-carnitine, jejunum, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, plexo submucoso, lcsh:RC321-571
Abstract

The effect of the treatment with acetyl-L-carnitine (ALC) on neurons releasing the vasoactive intestinal polypeptide (VIP) of the submucous plexus in the jejunum of diabetic rats was the purpose of our investigation. Diabetes (DM) was induced by injecting streptozotocin endovenously (35mg/kg). After sacrificing the animals, the jejunum was collected and processed for VIP detection. Four groups were used: C (non-diabetic), CC (non-diabetic treated with ALC), D (diabetic), DC (diabetes treated with ALC). We analyzed the immunoreactivity and the cellular profile of 126 cell bodies. The treatment with ALC improved some aspects of DM. However, it promoted a small increase in the area of neurons from group CC, suggesting a possible neurotrophic effect. Neurons from groups D and DC showed a large increase in their cellular profile and immunoreactivity when compared to C and CC, suggesting a larger concentration of this neurotransmitter within the neurons that produce it. This observation constitutes a recurrent finding in diabetic animals, suggesting that ALC doesnot interfere in the pathophysiological mechanisms that unchain a higher production and/or neurotransmitter accumulation and increase the profile of the VIP-ergic neurons.Investigamos o efeito da acetil-L-carnitina (ALC) sobre os neurônios que expressam o peptídeo intestinal vasoativo (VIP) do plexo submucoso no jejuno de ratos diabéticos. O diabetes (DM) foi induzido pela administração endovenosa de estreptozootocina (35mg/kg). Após o sacrifício dos animais, o jejuno foi coletado e processado para a detecção de VIP. Utilizou-se quatro grupos: C (não diabéticos), CC (não diabéticos suplementados com ALC), D (diabéticos) e DC (diabéticos suplementados com ALC). Analisou-se a imunoreatividade e o perfil celular de 126 corpos celulares. O tratamento com ALC melhorou alguns aspectos do DM. Porém, promoveu pequeno aumento na área dos neurônios do grupo CC, indicando possível efeito neurotrófico. Neurônios dos grupos D e DC apresentaram grande aumento do perfil celular e na imunoreatividade em relação a C e CC, sugerindo maior concentração deste neurotransmissor nestes neurônios. Esta observação é constante em animais diabéticos, sugerindo que a ALC não interfere nos mecanismos fisiopatológicos que desencadeiam a maior produção e/ou acúmulo de neurotransmissor e aumento do perfil dos neurônios VIP-érgicos.

Published
2003

4. Terminal ileum submucous plexus: Study of the VIP-ergic neurons of diabetic rats treated with ascorbic acid Plexo submucoso de íleo terminal: estudo dos neurônios VIP-érgicos de ratos diabéticos tratados com ácido ascórbico

Author

Jacqueline Nelisis Zanoni, Luzmarina Hernandes, Roberto Barbosa Bazotte, and Marcílio Hubner de Miranda Neto

Subjects
submucous plexus, acido ascórbico, ratos, peptídeo intestinal vasoativo, íleo, streptozotocin, estreptozootocina, lcsh:RC321-571, rats, diabetes mellitus, ascorbic acid, ileum, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, hormones, hormone substitutes, and hormone antagonists, plexo submucoso, vasoactive intestinal peptide
Abstract

The aim of this study was to evaluate the effect of the ascorbic acid (AA) supplementation on the neurons that produce the vasoactive intestinal peptide (VIP) in the submucous plexus of the ileum of rat, four months after the induction of experimental diabetes mellitus with streptozotocin. Three groups of rats were used: C - control, D - diabetic, DA - diabetic receiving AA. We have measured the immunoreactivity and area of 80 cellular bodies of VIP-ergic neurons from each studied group. In the diabetic animals, we have observed hyperphagia, polydipsia, and an increase of glycemia and glycated hemoglobin. The VIP-ergic neurons have presented an increase of their immunoreactivity and the highest profiles when compared to the other groups. In the diabetic animals supplemented with AA it has been observed a small reduction in the glycemia and the water and food intake. We have also noticed smaller immunoreactivity in their VIP-ergic neurons, similar to what we have observed in the control group animals (group C).O objetivo deste estudo foi avaliar o efeito da suplementação com ácido ascórbico (AA) sobre os neurônios que expressam o peptídeo intestinal vasoativo (VIP) no plexo submucoso do íleo de ratos, quatro meses após a indução do diabetes mellitus experimental com estreptozootocina. Três grupos de ratos foram usados: C- controles, D- diabéticos, DA- diabéticos recebendo AA. Foram avaliadas a imunoreatividade e a área de 80 corpos celulares de neurônios VIP-érgicos de cada grupo estudado. Nos animais diabéticos ocorreram hirperfagia, polidipsia, elevação da glicemia e hemoglobina glicada. Os neurônios VIP-érgicos apresentaram aumento da imunorreatividade e os maiores perfis, quando comparados aos demais grupos. Nos animais diabéticos suplementados com AA observou-se pequena redução na glicemia, ingesta de água e de alimento, verificando-se também menor imunorreatividade nos neurônios VIP-érgicos, o que foi semelhante ao observado nos animais do grupo controle (grupo C).

Published
2002

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