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1. Development of Anatomophysiologic Knowledge Regarding the Cardiovascular System: From Egyptians to Harvey

Author

Reinaldo Bulgarelli Bestetti, Carolina Baraldi A. Restini, and Lucélio B. Couto

Subjects
Sistema Cardiovascular, Conhecimento, Civilização / história, Egito, Mundo Grego / história, Antropologia Cultural / tendências, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Our knowledge regarding the anatomophysiology of the cardiovascular system (CVS) has progressed since the fourth millennium BC. In Egypt (3500 BC), it was believed that a set of channels are interconnected to the heart, transporting air, urine, air, blood, and the soul. One thousand years later, the heart was established as the center of the CVS by the Hippocratic Corpus in the medical school of Kos, and some of the CVS anatomical characteristics were defined. The CVS was known to transport blood via the right ventricle through veins and the pneuma via the left ventricle through arteries. Two hundred years later, in Alexandria, following the development of human anatomical dissection, Herophilus discovered that arteries were 6 times thicker than veins, and Erasistratus described the semilunar valves, emphasizing that arteries were filled with blood when ventricles were empty. Further, 200 years later, Galen demonstrated that arteries contained blood and not air. With the decline of the Roman Empire, Greco-Roman medical knowledge about the CVS was preserved in Persia, and later in Islam where, Ibn Nafis inaccurately described pulmonary circulation. The resurgence of dissection of the human body in Europe in the 14th century was associated with the revival of the knowledge pertaining to the CVS. The main findings were the description of pulmonary circulation by Servetus, the anatomical discoveries of Vesalius, the demonstration of pulmonary circulation by Colombo, and the discovery of valves in veins by Fabricius. Following these developments, Harvey described blood circulation.

Published
2014
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2. Comparação do desfecho entre a cardiopatia chagásica e a miocardiopatia dilatada idiopática

Author

Amanda Pires Barbosa, Augusto Cardinalli Neto, Ana Paula Otaviano, Bianca Faria Rocha, and Reinaldo Bulgarelli Bestetti

Subjects
Doença de chagas, cardiomiopatia chagásica, cardiomiopatia dilatada, tripanossomose, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

FUNDAMENTO: Pouco se sabe sobre o desfecho dos pacientes com cardiopatia chagásica, em comparação aos pacientes com miocardiopatia dilatada idiopática na era contemporânea. OBJETIVO: Comparar o desfecho dos pacientes chagásicos com insuficiência cardíaca sistólica crônica decorrente da cardiopatia chagásica ao observado em pacientes com MDI na era contemporânea. MÉTODOS: Foi incluído um total de 352 pacientes (246 com cardiomiopatia chagásica e 106 com miocardiopatia dilatada idiopática), seguidos prospectivamente em nossa Instituição, de janeiro de 2000 a janeiro de 2008. Todos os pacientes receberam tratamento clínico contemporâneo padrão. RESULTADOS: Na análise multivariada com o modelo de risco proporcional de Cox, o uso da digoxina (relação de risco = 3,17; intervalo de confiança de 95%, de 1,62 a 6,18; p = 0,001) necessitou de suporte inotrópico (relação de risco = 2,08; intervalo de confiança de 95%, de 1,43 a 3,02; p < 0,005). A fração de ejeção do ventrículo esquerdo (relação de risco = 0,97; intervalo de confiança de 95%, de 0,95 a 0,99; p < 0,005) e a etiologia da cardiopatia chagásica (relação de risco = 3,29; intervalo de confiança de 95%, de 1,89 a 5,73; p < 0,005) foram associadas positivamente à mortalidade, enquanto a terapia com betabloqueadores (relação de risco = 0,39; intervalo de confiança de 95%, de 0,26 a 0,56; p < 0,005) foi associada negativamente à mortalidade. A probabilidade de sobrevida para pacientes com cardiomiopatia chagásica em oito, 24 e 49 meses foi de 83%, 61% e 41%, respectivamente. Já para pacientes com cardiomiopatia dilatada idiopática, foi de 97%, 92% e 82%, respectivamente (p < 0,005). CONCLUSÃO: Na era atual do tratamento da insuficiência cardíaca, os pacientes com cardiomiopatia chagásica têm um desfecho pior em comparação aos pacientes com cardiomiopatia dilatada idiopática.

Published
2011

3. III Diretriz Brasileira de Insuficiência Cardíaca Crônica

Author

Edimar Alcides Bocchi, Fabiana Goulart Marcondes Braga, Silvia Moreira Ayub Ferreira, Luis Eduardo Paim Rohde, Wilson Alves de Oliveira, Dirceu Rodrigues de Almeida, Maria da Consolação Vieira Moreira, Reinaldo Bulgarelli Bestetti, Solange Bordignon, Clério Azevedo, Evandro Mesquita Tinoco, Ricardo Mourilhe Rocha, Victor Sarli Issa, Almir Ferraz, Fátima das Dores Cruz, Guilherme Veiga Guimarães, Vanessa dos Santos Pereira Montera, Denilson Campos Albuquerque, Fernando Bacal, Germano Emilio Conceição Souza, João Manoel Rossi Neto, Nadine Oliveira Clausell, Silvia Marinho Martins, Alexandre Siciliano, João David de Souza Neto, Luis Felipe Moreira, Ricardo Alkmim Teixeira, Lídia Zytynski Moura, Luís Beck-da-Silva, Salvador Rassi, Estela Azeka, Estela Horowitz, Felix Ramires, Marcus Vinicius Simões, Renato Barroso Pereira de Castro, Vera Maria Cury Salemi, Humberto Villacorta Junior, José Henrique Vila, Ricardo Simões, Francisco Albanesi, and Marcelo Westerlund Montera

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Published
2009
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4. Emerging Topics Update of the Brazilian Heart Failure Guideline - 2021

Author

Fabiana G, Marcondes-Braga, Lídia Ana Zytynski, Moura, Victor Sarli, Issa, Jefferson Luis, Vieira, Luis Eduardo, Rohde, Marcus Vinícius, Simões, Miguel Morita, Fernandes-Silva, Salvador, Rassi, Silvia Marinho Martins, Alves, Denilson Campos de, Albuquerque, Dirceu Rodrigues de, Almeida, Edimar Alcides, Bocchi, Felix José Alvarez, Ramires, Fernando, Bacal, João Manoel, Rossi Neto, Luiz Claudio, Danzmann, Marcelo Westerlund, Montera, Mucio Tavares de, Oliveira Junior, Nadine, Clausell, Odilson Marcos, Silvestre, Reinaldo Bulgarelli, Bestetti, Sabrina, Bernadez-Pereira, Aguinaldo F, Freitas, Andréia, Biolo, Antonio Carlos Pereira, Barretto, Antônio José Lagoeiro, Jorge, Bruno, Biselli, Carlos Eduardo Lucena, Montenegro, Edval Gomes Dos, Santos Júnior, Estêvão Lanna, Figueiredo, Fábio, Fernandes, Fabio Serra, Silveira, Fernando Antibas, Atik, Flávio de Souza, Brito, Germano Emílio Conceição, Souza, Gustavo Calado de Aguiar, Ribeiro, Humberto, Villacorta, João David de, Souza Neto, Livia Adams, Goldraich, Luís, Beck-da-Silva, Manoel Fernandes, Canesin, Marcelo Imbroinise, Bittencourt, Marcely Gimenes, Bonatto, Maria da Consolação Vieira, Moreira, Mônica Samuel, Avila, Otavio Rizzi, Coelho Filho, Pedro Vellosa, Schwartzmann, Ricardo, Mourilhe-Rocha, Sandrigo, Mangini, Silvia Moreira Ayub, Ferreira, José Albuquerque de, Figueiredo Neto, and Evandro Tinoco, Mesquita

Subjects
Heart Failure, Humans, American Heart Association, Atualização, Brazil, Update
Published
2021

5. Prevalence of hypertension in the urban population of Catanduva, in the State of São Paulo, Brazil

Author

Olavo de Carvalho Freitas, Fabiano Resende de Carvalho, Juliana Marques Neves, Paula Karine Veludo, Ricardo Silva Parreira, Rodrigo Marafiotti Gonçalves, Simone Arenales de Lima, and Reinaldo Bulgarelli Bestetti

Subjects
hypertension, antihypertensive treatment, epidemiological study of hypertension, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

OBJECTIVE: To study the prevalence of systemic hypertension and its control in the population of Catanduva, in the state of São Paulo, Brazil. METHODS: We carried out a randomized cross-sectional population-based study of the urban population of Catanduva with individuals above 18 years of age (688 individuals accounting for 0.9% of the referred population). We interviewed study participants to analyze the major qualitative and quantitative variables that could influence the hypertensive scenario and the risk for systemic hypertension. Blood pressure was measured through the indirect method according to the III Consenso Brasileiro de Hipertensão (III Brazilian Consensus on Hypertension), which established blood pressure levels > or = 140/90 mm Hg as hypertensive. RESULTS: The prevalence of systemic hypertension was higher in individuals with: (1) history of hypertension (p or = 25 kg/m² (p

Published
2001
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6. Atualização de Tópicos Emergentes da Diretriz Brasileira de Insuficiência Cardíaca, 2021

Author

Marcondes-Braga, Fabiana G., Zytynski Moura, Lidia Ana, Issa, Victor Sarli, Vieira, Jefferson Luis, Rohde, Luis Eduardo, Simoes, Marcus Vinicius, Fernandes-Silva, Miguel Morita, Rassi, Salvador, Martins Alves, Silvia Marinho, de Albuquerque, Denilson Campos, de Almeida, Dirceu Rodrigues, Bocchi, Edimar Alcides, Alvarez Ramires, Felix Jose, Bacal, Fernando, Rossi Neto, Joao Manoel, Danzmann, Luiz Claudio, Montera, Marcelo Westerlund, de Oliveira Junior, Mucio Tavares, Clausell, Nadine, Silvestre, Odilson Marcos, Bestetti, Reinaldo Bulgarelli, Bernadez-Pereira, Sabrina, Freitas Jr, Aguinaldo F., Biolo, Andreia, Pereira Barretto, Antonio Carlos, Lagoeiro Jorge, Antonio Jose, Biselli, Bruno, Lucena Montenegro, Carlos Eduardo, Dos Santos Junior, Edval Gomes, Figueiredo, Estevao Lanna, Fernandes, Fabio, Silveira, Fabio Serra, Atik, Fernando Antibas, de Brito, Flavio Souza, Conceicao Souza, Germano Emilio, de Aguiar Ribeiro, Gustavo Calado, Villacorta, Humberto, de Souza Neto, Joao David, Goldraich, Livia Adams, Beck-da-Silva, Luis, Canesin, Manoel Fernandes, Bittencourt, Marcelo Imbroinise, Bonatto, Marcely Gimenes, Vieira Moreira, Maria da Consolacao, Avila, Monica Samuel, Coelho Filho, Otavio Rizzi, Schwartzmann, Pedro Vellosa, Mourilhe-Rocha, Ricardo, Mangini, Sandrigo, Ayub Ferreira, Silvia Moreira, de Figueiredo Neto, Jose Albuquerque, and Mesquita, Evandro Tinoco

Subjects
Human medicine
Published
2021

7. II Diretriz Brasileira de Transplante Cardíaco

Author

Fernando Bacal, João David de Souza Neto, Alfredo Inácio Fiorelli, Juan Mejia, Fabiana Goulart Marcondes-Braga, Sandrigo Mangini, José de Lima Oliveira Jr, Dirceu Rodrigues de Almeida, Estela Azeka, Jarbas Jakson Dinkhuysen, Maria da Consolação Vieira Moreira, João Manoel Rossi Neto, Reinaldo Bulgarelli Bestetti, Juliana Rolim Fernandes, Fátima das Dores Cruz, Lucinei Paz Ferreira, Helenice Moreira da Costa, Ana Augusta Maria Pereira, Nicolas Panajotopoulos, Luiz Alberto Benvenuti, Lídia Zytynski Moura, Glauber Gean Vasconcelos, João Nelson Rodrigues Branco, Claudio Leo Gelape, Ricardo Barreira Uchoa, Silvia Moreira Ayub-Ferreira, Luis Fernando Aranha Camargo, Alexandre Siciliano Colafranceschi, Solange Bordignon, Reginaldo Cipullo, Estela Suzana Kleiman Horowitz, Klébia Castelo Branco, Marcelo Jatene, Sergio Lopes Veiga, Cesar Augusto Guimarães Marcelino, Guaracy Fernandes Teixeira Filho, José Henrique Vila, and Marcelo Westerlund Montera

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Published
2010
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8. Diretriz Brasileira de Insuficiência Cardíaca Crônica e Aguda

Author

Rohde, Luis Eduardo Paim, primary, Montera, Marcelo Westerlund, additional, Bocchi, Edimar Alcides, additional, Clausell, Nadine Oliveira, additional, Albuquerque, Denilson Campos de, additional, Rassi, Salvador, additional, Colafranceschi, Alexandre Siciliano, additional, Freitas Junior, Aguinaldo Figueiredo de, additional, Ferraz, Almir Sergio, additional, Biolo, Andreia, additional, Barretto, Antonio C. Pereira, additional, Ribeiro, Antonio Luiz Pinho, additional, Polanczyk, Carisi Anne, additional, Gualandro, Danielle Menosi, additional, Almeida, Dirceu Rodrigues, additional, Silva, Eneida Rejane Rabelo da, additional, Figueiredo, Estêvão Lanna, additional, Mesquita, Evandro Tinoco, additional, Marcondes-Braga, Fabiana G., additional, Cruz, Fátima das Dores da, additional, Ramires, Felix José Alvarez, additional, Atik, Fernando Antibas, additional, Bacal, Fernando, additional, Souza, Germano Emilio Conceição, additional, Almeida Junior, Gustavo Luiz Gouvêa de, additional, Ribeiro, Gustavo Calado de Aguiar, additional, Villacorta Junior, Humberto, additional, Vieira, Jefferson Luís, additional, Souza Neto, João David de, additional, Rossi Neto, João Manoel, additional, Figueiredo Neto, Jose Albuquerque de, additional, Moura, Lidia Ana Zytynsky, additional, Goldraich, Livia Adams, additional, Beck-da-Silva, Luis, additional, Danzmann, Luiz Claudio, additional, Canesin, Manoel Fernandes, additional, Bittencourt, Marcelo Imbroinise, additional, Garcia, Marcelo Iorio, additional, Bonatto, Marcely Gimenes, additional, Simões, Marcus Vinícius, additional, Moreira, Maria da Consolação Vieira, additional, Silva, Miguel Morita Fernandes da, additional, Olivera Junior, Mucio Tavares de, additional, Silvestre, Odilson Marcos, additional, Schwartzmann, Pedro Vellosa, additional, Bestetti, Reinaldo Bulgarelli, additional, Rocha, Ricardo Mourilhe, additional, Simões, Ricardo, additional, Pereira, Sabrina Bernardez, additional, Mangini, Sandrigo, additional, Alves, Sílvia Marinho Martins, additional, Ferreira, Silvia Moreira Ayub, additional, Issa, Victor Sarli, additional, Barzilai, Vitor Salvatore, additional, and Martins, Wolney de Andrade, additional

Published
2018
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9. Carlos Chagas Discoveries as a Drop Back to Scientific Construction of Chronic Chagas Heart Disease

Author

Carolina Baraldi Araujo Restini, Reinaldo Bulgarelli Bestetti, and Lucélio B. Couto

Subjects
Chagas Cardiomyopathy, lcsh:Diseases of the circulatory (Cardiovascular) system, medicine.medical_specialty, Heart disease, Biopsy, Arritmias Cardíacas, Insuficiência Cardíaca, Autopsy, Physical examination, Review Article, 030204 cardiovascular system & hematology, Doença de Chagas / história, Sudden cardiac death, Electrocardiography, Ventricular Dysfunction, Left, 03 medical and health sciences, Chagas Disease / history, 0302 clinical medicine, Internal medicine, Humans, Medicine, 030212 general & internal medicine, Heart Failure, medicine.diagnostic_test, business.industry, Cardiac arrhythmia, Arrhythmias, Cardiac, History, 20th Century, medicine.disease, Cardiomiopatia Chagásica, Echocardiography, lcsh:RC666-701, Heart failure, Chronic Disease, Heart catheterization, Exercise Test, Cardiology, Carlos Chagas, Cardiology and Cardiovascular Medicine, business, Brazil
Abstract

The scientific construction of chronic Chagas heart disease (CCHD) started in 1910 when Carlos Chagas highlighted the presence of cardiac arrhythmia during physical examination of patients with chronic Chagas disease, and described a case of heart failure associated with myocardial inflammation and nests of parasites at autopsy. He described sudden cardiac death associated with arrhythmias in 1911, and its association with complete AV block detected by Jacquet's polygraph as Chagas reported in 1912. Chagas showed the presence of myocardial fibrosis underlying the clinical picture of CCHD in 1916, he presented a full characterization of the clinical aspects of CCHD in 1922. In 1928, Chagas detected fibrosis of the conductive system, and pointed out the presence of marked cardiomegaly at the chest X-Ray associated with minimal symptomatology. The use of serological reaction to diagnose CCHD was put into clinical practice in 1936, after Chagas' death, which along with the 12-lead ECG, revealed the epidemiological importance of CCHD in 1945. In 1953, the long period between initial infection and appearance of CCHD was established, whereas the annual incidence of CCHD from patients with the indeterminate form of the disease was established in 1956. The use of heart catheterization in 1965, exercise stress testing in 1973, Holter monitoring in 1975, Electrophysiologic testing in 1973, echocardiography in 1975, endomyocardial biopsy in 1981, and Magnetic Resonance Imaging in 1995, added to the fundamental clinical aspects of CCHD as described by Carlos Chagas.

Published
2016

10. II Diretriz Brasileira de Transplante Cardíaco

Author

Bacal, Fernando, Souza Neto, João David de, Fiorelli, Alfredo Inácio, Mejia, Juan, Marcondes-Braga, Fabiana Goulart, Mangini, Sandrigo, Oliveira Junior, José de Lima, Almeida, Dirceu Rodrigues de [UNIFESP], Azeka, Estela, Dinkhuysen, Jarbas Jakson, Moreira, Maria da Consolação Vieira, Rossi Neto, João Manoel, Bestetti, Reinaldo Bulgarelli, Fernandes, Juliana Rolim, Cruz, Fátima das Dores, Ferreira, Lucinei Paz, Costa, Helenice Moreira da, Pereira, Ana Augusta Maria, Panajotopoulos, Nicolas, Benvenuti, Luiz Alberto, Moura, Lídia Zytynski, Vasconcelos, Glauber Gean, Branco, João Nelson Rodrigues [UNIFESP], Gelape, Claudio Leo, Uchoa, Ricardo Barreira, Ayub-Ferreira, Silvia Moreira, Camargo, Luis Fernando Aranha [UNIFESP], Colafranceschi, Alexandre Siciliano, Bordignon, Solange, Cipullo, Reginaldo, Horowitz, Estela Suzana Kleiman, Branco, Klébia Castelo, Jatene, Marcelo, Veiga, Sergio Lopes, Marcelino, Cesar Augusto Guimarães, Teixeira Filho, Guaracy Fernandes, Vila, José Henrique, Montera, Marcelo Westerlund, Universidade de São Paulo (USP), IIHospital de Messejana Dr. Carlos Alberto Studart Gomes, Universidade Federal de São Paulo (UNIFESP), Instituto Dante Pazzanese de Cardiologia, Universidade Federal de Minas Gerais Hospital das Clínicas, Faculdade de Medicina de São José do Rio Preto, Pontifícia Universidade Católica do Paraná, IHospital Israelita Albert Einstein, Instituto Nacional de Cardiologia, Fundação Universitária do Rio Grande do Sul Instituto de Cardiologia, Real e Benemérita Sociedade de Beneficência Portuguesa, São Paulo, Hospital Pró-Cardíaco do Rio de Janeiro, and Santa Casa do Rio de Janeiro

Subjects
lcsh:Diseases of the circulatory (Cardiovascular) system, Impact factor, lcsh:RC666-701, business.industry, MEDLINE, Library science, Medicine, Cardiology and Cardiovascular Medicine, business
Abstract

Universidade de São Paulo Faculdade de Medicina Hospital das Clínicas IIHospital de Messejana Dr. Carlos Alberto Studart Gomes Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Instituto Dante Pazzanese de Cardiologia Universidade Federal de Minas Gerais Hospital das Clínicas Faculdade de Medicina de São José do Rio Preto Pontifícia Universidade Católica do Paraná IHospital Israelita Albert Einstein Instituto Nacional de Cardiologia , Fundação Universitária do Rio Grande do Sul Instituto de Cardiologia Real e Benemérita Sociedade de Beneficência Portuguesa, São Paulo Hospital Pró-Cardíaco do Rio de Janeiro Santa Casa do Rio de Janeiro UNIFESP, EPM SciELO

Published
2010

11. Comprometimento parassimpático no estágio pré-clínico da doença de chagas crônica

Author

Augusto Cardinalli Neto, Reinaldo Bulgarelli Bestetti, and Paulo R. Nogueira

Subjects
lcsh:Diseases of the circulatory (Cardiovascular) system, medicine.medical_specialty, Ejection fraction, Heart disease, business.industry, Chronic Chagas' disease, medicine.disease, lcsh:RC666-701, Electrocardiographic abnormality, Internal medicine, Heart rate, cardiovascular system, medicine, Cardiology, Heart rate variability, In patient, cardiovascular diseases, Cardiology and Cardiovascular Medicine, Preclinical stage, business
Abstract

Dear Editor, We have read with great interest the paper by Vasconcelos and Junqueira-Junior1 who showed that parasympathetic and sympathetic abnormalities occur in patients with chronic Chagas heart disease with no left ventricular systolic dysfunction. These abnormalities were observed in heart rate variability in the time and frequency domain. They concluded that “it is improbable that the marked cardiac autonomic dysfunction can merely be a phenomenon secondary to slight ventricular mechanic disturbance”. We agree. We have demonstrated that only parasympathetic impairment can be observed in heart rate variability in the frequency domain of patients with chronic Chagas disease with no left ventricular systolic dysfunction2. We studied 97 patients, the left ventricular ejection fraction being similar in patients with and in those without parasympathetic impairment. Nonetheless, 8 (8%) of 97 patients with no electrocardiographic abnormality in the 12-lead electrocardiogram and no left ventricular systolic dysfunction at echocardiography had parasympathetic impairment. By contrast, sympathetic derangement was not observed in any of the patients with normal 12-lead electrocardiogram and echocardiogram. However, in patients with chronic Chagas heart disease, as observed in the study by Vasconcelos e Junqueira-Junior, the proportion of sympathetic and parasympathetic dysfunction was similar to that found in our study.

Published
2012

12. Diretriz Brasileira de Insuficiência Cardíaca Crônica e Aguda

Author

Luis Eduardo Paim Rohde, Marcelo Westerlund Montera, Edimar Alcides Bocchi, Nadine Oliveira Clausell, Denilson Campos de Albuquerque, Salvador Rassi, Alexandre Siciliano Colafranceschi, Aguinaldo Figueiredo de Freitas Junior, Almir Sergio Ferraz, Andreia Biolo, Antonio C. Pereira Barretto, Antonio Luiz Pinho Ribeiro, Carisi Anne Polanczyk, Danielle Menosi Gualandro, Dirceu Rodrigues Almeida, Eneida Rejane Rabelo da Silva, Estêvão Lanna Figueiredo, Evandro Tinoco Mesquita, Fabiana G. Marcondes-Braga, Fátima das Dores da Cruz, Felix José Alvarez Ramires, Fernando Antibas Atik, Fernando Bacal, Germano Emilio Conceição Souza, Gustavo Luiz Gouvêa de Almeida Junior, Gustavo Calado de Aguiar Ribeiro, Humberto Villacorta Junior, Jefferson Luís Vieira, João David de Souza Neto, João Manoel Rossi Neto, Jose Albuquerque de Figueiredo Neto, Lidia Ana Zytynsky Moura, Livia Adams Goldraich, Luis Beck-da-Silva, Luiz Claudio Danzmann, Manoel Fernandes Canesin, Marcelo Imbroinise Bittencourt, Marcelo Iorio Garcia, Marcely Gimenes Bonatto, Marcus Vinícius Simões, Maria da Consolação Vieira Moreira, Miguel Morita Fernandes da Silva, Mucio Tavares de Olivera Junior, Odilson Marcos Silvestre, Pedro Vellosa Schwartzmann, Reinaldo Bulgarelli Bestetti, Ricardo Mourilhe Rocha, Ricardo Simões, Sabrina Bernardez Pereira, Sandrigo Mangini, Sílvia Marinho Martins Alves, Silvia Moreira Ayub Ferreira, Victor Sarli Issa, Vitor Salvatore Barzilai, and Wolney de Andrade Martins

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
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13. Comparison of outcome between Chagas cardiomyopathy and idiopathic dilated cardiomyopathy

Author

Amanda Pires, Barbosa, Augusto, Cardinalli Neto, Ana Paula, Otaviano, Bianca Faria, Rocha, and Reinaldo Bulgarelli, Bestetti

Subjects
Cardiomyopathy, Dilated, Chagas Cardiomyopathy, Male, Digoxin, Treatment Outcome, Adrenergic beta-Antagonists, Humans, Female, Middle Aged, Epidemiologic Methods, Prognosis, Ultrasonography
Abstract

Little is known about the outcome of patients with Chagas cardiomyopathy in comparison to that of patients with idiopathic dilated cardiomyopathy in the contemporary era.To compare the outcome of chagasic patients with chronic systolic heart failure secondary to Chagas cardiomyopathy with that observed in patients with IDC in the contemporary era.A total of 352 patients (246 with Chagas cardiomyopathy, 106 with idiopathic dilated cardiomyopathy) prospectively followed at our Institution from January, 2000 to January, 2008 were included. All patients received standard contemporary medical therapy.In Cox proportional hazards model multivariate analysis, digoxin use (Hazard Ratio=3.17; 95% Confidence Interval 1.62 to 6.18; p=0.001), need of inotropic support (Hazard Ratio=2.08; 95% Confidence Interval 1.43 to 3.02; p0.005), left ventricular ejection fraction (Hazard Ratio=0.97; 95% Confidence Interval 0.95 to 0.99; p0.005), and Chagas cardiomyopathy etiology (Hazard Ratio=3.29; 95% Confidence Interval 1.89 to 5.73; p0.005) were positively associated with mortality, whereas beta-blocker therapy (Hazard Ratio=0.39; 95% Confidence Interval 0.26 to 0.56; p0.005) was negatively associated with mortality. Survival probability for patients with Chagas cardiomyopathy at 8, 24, and 49 months was 83%, 61%, and 41%, respectively, and for patients with idiopathic dilated cardiomyopathy 97%, 92%, and 82%, respectively (p0.005).In the current era of heart failure therapy, patients with Chagas cardiomyopathy have a poorer outcome in comparison to patients with idiopathic dilated cardiomyopathy.

Published
2011

14. [III Brazilian Guidelines on Chronic Heart Failure]

Author

Edimar Alcides, Bocchi, Fabiana Goulart Marcondes, Braga, Silvia Moreira Ayub, Ferreira, Luis Eduardo Paim, Rohde, Wilson Alves de, Oliveira, Dirceu Rodrigues de, Almeida, Maria da Consolação Vieira, Moreira, Reinaldo Bulgarelli, Bestetti, Solange, Bordignon, Clério, Azevedo, Evandro Mesquita, Tinoco, Ricardo Mourilhe, Rocha, Victor Sarli, Issa, Almir, Ferraz, Fátima das Dores, Cruz, Guilherme Veiga, Guimarães, Vanessa Dos Santos Pereira, Montera, Denilson Campos, Albuquerque, Fernando, Bacal, Germano Emilio Conceição, Souza, João Manoel, Rossi Neto, Nadine Oliveira, Clausell, Silvia Marinho, Martins, Alexandre, Siciliano, João David de, Souza Neto, Luis Felipe, Moreira, Ricardo Alkmim, Teixeira, Lídia Zytynski, Moura, Luís, Beck-da-Silva, Salvador, Rassi, Estela, Azeka, Estela, Horowitz, Felix, Ramires, Marcus Vinicius, Simões, Renato Barroso Pereira de, Castro, Vera Maria Cury, Salemi, Humberto, Villacorta Junior, José Henrique, Vila, Ricardo, Simões, Francisco, Albanesi, and Marcelo Westerlund, Montera

Subjects
Heart Failure, Chronic Disease, Humans, Brazil
Published
2010

15. [II Brazilian Guidelines for Cardiac Transplantation]

Author

Fernando, Bacal, João David de Souza, Neto, Alfredo Inácio, Fiorelli, Juan, Mejia, Fabiana Goulart, Marcondes-Braga, Sandrigo, Mangini, José de Lima, Oliveira, Dirceu Rodrigues, de Almeida, Estela, Azeka, Jarbas Jakson, Dinkhuysen, Maria da Consolação Vieira, Moreira, João Manoel Rossi, Neto, Reinaldo Bulgarelli, Bestetti, Juliana Rolim, Fernandes, Fátima das Dores, Cruz, Lucinei Paz, Ferreira, Helenice Moreira, da Costa, Ana Augusta Maria, Pereira, Nicolas, Panajotopoulos, Luiz Alberto, Benvenuti, Lídia Zytynski, Moura, Glauber Gean, Vasconcelos, João Nelson Rodrigues, Branco, Claudio Leo, Gelape, Ricardo Barreira, Uchoa, Silvia Moreira, Ayub-Ferreira, Luis Fernando Aranha, Camargo, Alexandre Siciliano, Colafranceschi, Solange, Bordignon, Reginaldo, Cipullo, Estela Suzana Kleiman, Horowitz, Klébia Castelo, Branco, Marcelo, Jatene, Sergio Lopes, Veiga, Cesar Augusto Guimarães, Marcelino, Guaracy Fernandes, Teixeira Filho, José Henrique, Vila, and Marcelo Westerlund, Montera

Subjects
Tissue and Organ Procurement, Heart Transplantation, Humans, Brazil, Tissue Donors
Published
2010

17. Atualização de Tópicos Emergentes da Diretriz Brasileira de Insuficiência Cardíaca – 2021

Author

Fabiana G. Marcondes-Braga, Lídia Ana Zytynski Moura, Victor Sarli Issa, Jefferson Luis Vieira, Luis Eduardo Rohde, Marcus Vinícius Simões, Miguel Morita Fernandes-Silva, Salvador Rassi, Silvia Marinho Martins Alves, Denilson Campos de Albuquerque, Dirceu Rodrigues de Almeida, Edimar Alcides Bocchi, Felix José Alvarez Ramires, Fernando Bacal, João Manoel Rossi Neto, Luiz Claudio Danzmann, Marcelo Westerlund Montera, Mucio Tavares de Oliveira Junior, Nadine Clausell, Odilson Marcos Silvestre, Reinaldo Bulgarelli Bestetti, Sabrina Bernadez-Pereira, Aguinaldo F. Freitas Jr, Andréia Biolo, Antonio Carlos Pereira Barretto, Antônio José Lagoeiro Jorge, Bruno Biselli, Carlos Eduardo Lucena Montenegro, Edval Gomes dos Santos Júnior, Estêvão Lanna Figueiredo, Fábio Fernandes, Fabio Serra Silveira, Fernando Antibas Atik, Flávio de Souza Brito, Germano Emílio Conceição Souza, Gustavo Calado de Aguiar Ribeiro, Humberto Villacorta, João David de Souza Neto, Livia Adams Goldraich, Luís Beck-da-Silva, Manoel Fernandes Canesin, Marcelo Imbroinise Bittencourt, Marcely Gimenes Bonatto, Maria da Consolação Vieira Moreira, Mônica Samuel Avila, Otavio Rizzi Coelho Filho, Pedro Vellosa Schwartzmann, Ricardo Mourilhe-Rocha, Sandrigo Mangini, Silvia Moreira Ayub Ferreira, José Albuquerque de Figueiredo Neto, and Evandro Tinoco Mesquita

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
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