1. Novo Método Melhora Avaliação da Disfunção Ventricular Esquerda Subclínica no Diabetes Mellitus Tipo 2
- Author
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Askin, Lutfu, Tanrıverdi, Okan, Tibilli, Hakan, and Turkmen, Serdar
- Subjects
Dyastole ,Adult ,Male ,lcsh:Diseases of the circulatory (Cardiovascular) system ,Antioxidantes/farmacologia ,Systole ,Espécies Reativas de Oxigênio ,Insuficiência Cardíaca ,Statistics, Nonparametric ,Ventricular Function, Left ,Body Mass Index ,Ventricular Dysfunction, Left ,Reference Values ,Risk Factors ,Diabetes Mellitus ,Myocardial ,Humans ,Aged ,Heart Failure ,Apoptosis/drug effects ,Heart ,Stroke Volume ,Sístole ,Middle Aged ,Apoptose/efeitos dos fármacos ,Diabetes Mellitus Type 2 ,Echocardiography, Doppler ,Cross-Sectional Studies ,Ventricular Dysfunction,Left ,Antioxidants/pharmacology ,Diabetes Mellitus, Type 2 ,lcsh:RC666-701 ,Heart/physiopathology ,Diástole ,Female ,Original Article ,Short Editorial ,Reactive Oxygen Species ,Miocárdio - Abstract
Background Myocardial performance index (MPI), demonstrates both systolic and diastolic functions of the left ventricle. Presystolic wave (PSW) is frequently detected on Doppler examination of the left ventricular outflow tract and possible mechanism of PSW is impaired LV compliance and left ventricular stiffness. Objective To investigate the relationship between PSW and MPI in type 2 diabetic patients. Method A total of 129 type 2 diabetic patients were included in this study. Patients were divided into two groups according to the presence of PSW on Doppler echocardiography. There were 90 patients (38 male, mean age 57.77 ± 10.91 years) in the PSW-positive group and 39 patients (13 male; mean age: 55.31 ± 11.29 years) in the PSW-negative group. The p values of < 0.05 were considered statistically significant. Results MPI was higher in PSW- positive group (0.63 ± 0.17vs 0.52 ± 0.13, p < 0.001). In addition, subclinical left ventricle dysfunction (LVD) was higher in the PSW- positive group (p = 0.029). Univariate analysis showed that the presence of PSW associated with abnormal MPI (p = 0.031). Pearson correlation analysis showed that PSW velocity correlated with MPI (r: 0.286, p = 0.006). Conclusion Presence of the PSW on Doppler examination was associated with subclinical LV dysfunction in patients with DM type 2. This easy-to-perform echocardiographic parameter may be related to subclinical LVD among patients with type 2 DM.
- Published
- 2019