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A new chiral ligand derived from natural tartaric acid was synthesized and was applied to the asymmetric addition of diethylzinc to aldehyde and ketones. Moderate to good enantioselectivities were obtained in the asymmetric addition of diethylzinc to ketones with 10% mol catalyst loading at room temperature.

A variety of camphor sulfonamide ligands were synthesized and employed in the addition of diethylzinc to aldehydes. The influences of substitution patterns, electronic property, reaction substrates, reaction solvents and temperature were studied. After optimization, the best reaction condition was determined and applied to this addition reaction, giving the corresponding products in high yields with up to 83% ee.