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Pyridazino[4,5-b]indole is an important class of heterocyclic compounds with numerous applications in the field of medicinal chemistry. This review summarizes the synthetic methods of pyridazino[4,5-b]indoles published during the period from 1962 to 2022. In this review, we have discussed different methods for the synthesis of pyridazino[4,5-b]indole from various starting materials and the difficulties that scientists faced during the preparation process. We focus on the recent developments in synthetic methods of the pyridazino [4,5-b]indoles. [ABSTRACT FROM AUTHOR]

The nucleus of pyridazino[4,5-b]indoles contains two heterocyclic moieties that interact with many receptors. They are an important class of heterocyclic compounds with diverse applications in the field of medicinal chemistry. This review summarizes the reactions and biological importance of pyridazino[4,5-b] indoles during the period from 1962 to 2023. The reactions involve chlorination, hydrazinolysis, functionalization of pyridazino[4,5-b]indoles at positions 1, 2, or 5 and others dealing with reactions occuring at positions 1 and 3. This review article will include the latest advances on the applications of the pyridazino[4,5-b]indoles. [ABSTRACT FROM AUTHOR]