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Your search keyword '"Shadrin, V. O.' showing total 2 results
Start Over Author "Shadrin, V. O. Journal arkhiv patologii
2 results on '"Shadrin, V. O.'

1. [Influence of recombinant interleukin-2 on the course and pathomorphology of intraperitoneal staphylococcal infection in mice]

Author

O Ia, Kaufman, S N, Bykovskaia, O V, Shadrin, and B V, Shlopov

Subjects
Male, Mice, Liver, Neutrophils, Animals, Interleukin-2, Female, Staphylococcal Infections, Lymphocyte Activation, Cell Division, Injections, Intraperitoneal, Recombinant Proteins
Abstract

Resistance to the lethal doses of the infectious agent (3 DL100) develops in mice 6 days after the intraperitoneal non-lethal dose of staphylococcus in combination with recombinant interleukin-2 (RIL-2). This effect may be due to the activation of T- and B-dependent zones of the regional lymph nodes and spleen, activation and proliferation of the liver stellate reticulo-endotheliocytes, enhancement of the phagocytic activity of the circulating neutrophil granulocytes. These structural and functional mechanisms may be due to both direct RIL-2 effect in combination with an antigenic stimulation and indirect effect through other interleukins produced by lymphocytes activated by RIL-2.

Published
1991

2. [Influence of recombinant interleukin-2 on the course and pathomorphology of intraperitoneal staphylococcal infection in mice].

Author

Kaufman OIa, Bykovskaia SN, Shadrin OV, and Shlopov BV

Subjects
Animals, Cell Division drug effects, Female, Injections, Intraperitoneal, Liver cytology, Liver drug effects, Lymphocyte Activation drug effects, Male, Mice, Neutrophils drug effects, Recombinant Proteins therapeutic use, Staphylococcal Infections drug therapy, Interleukin-2 therapeutic use, Staphylococcal Infections pathology
Abstract

Resistance to the lethal doses of the infectious agent (3 DL100) develops in mice 6 days after the intraperitoneal non-lethal dose of staphylococcus in combination with recombinant interleukin-2 (RIL-2). This effect may be due to the activation of T- and B-dependent zones of the regional lymph nodes and spleen, activation and proliferation of the liver stellate reticulo-endotheliocytes, enhancement of the phagocytic activity of the circulating neutrophil granulocytes. These structural and functional mechanisms may be due to both direct RIL-2 effect in combination with an antigenic stimulation and indirect effect through other interleukins produced by lymphocytes activated by RIL-2.

Published
1991

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