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Distribution in the organism of the tantalum after its application on the brain surgical wound was studied by light microscopy and atomic-emission spectrum analysis with an induction-linked plasma in patients dying from neuro oncological diseases. It is found that in all cases a partial tantalum migration into various brain regions and internal organs occurs. Blood cells are able to fix the tantalum particles in vivo and in vitro, this process being enhanced after a preceding angiography.

The time-course of healing of a perforating gunshot wound of soft tissues after primary surgical treatment was studied histologically, histochemically and electron microscopically in 24 rabbits. Throughout the observation period (1-28 days) disorders of the microcirculation, inflammatory reaction, degenerative and necrotic changes, disorders of the ultrastructure and metabolic processes in cells were observed in the wound tissues. Morphological changes developed in the zone of molecular concussion the presence of which delayed healing of the gunshot wound and reduced the efficiency of the primary surgical treatment. The experimental results extend current knowledge of the morpho-functional features of healing of gunshot wounds and indicate the proper choice of rational methods for surgical treatment.