1. Intestinal Nematode Infection Affects Metastasis of EL4 Lymphoma Cells
- Author
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Katarzyna Donskow-Łysoniewska, Klaudia Brodaczewska, Maja Machcińska, and Katarzyna Krawczak
- Subjects
Male ,Lung Neoplasms ,Lymphoma ,Short Communication ,medicine.medical_treatment ,Immunology ,Helminthiasis ,Biology ,Metastasis ,Immunomodulation ,Mice ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,Transforming Growth Factor beta ,medicine ,Animals ,Immunology and Allergy ,Mesenteric lymph nodes ,Intestinal Diseases, Parasitic ,Neoplasm Metastasis ,Nematode Infections ,030304 developmental biology ,Nematospiroides dubius ,0303 health sciences ,Lung ,Immunosuppression ,General Medicine ,medicine.disease ,biology.organism_classification ,Disease Models, Animal ,medicine.anatomical_structure ,Intestinal nematodes ,Cancer cell ,Cancer research ,Heligmosomoides polygyrus ,Tumour ,030217 neurology & neurosurgery - Abstract
An effective host immune system prevents the growth of most cancer cells. However, as intestinal nematodes are able to induce both immunotolerance and immunosuppression in the host, it is possible that their presence could allow co-occurring cancer cells to proliferate and metastasize. Our findings indicate that previous, subsequent or concurrent intestinal nematode infection affects the formation of lung metastatic nodules in mice experimentally infected with Heligmosomoides polygyrus. In addition, pre-infection with nematodes renders mice resistant to metastasis development in lungs, with the inoculated EL4 cancer cells being located mainly in mesenteric lymph nodes. The present paper discusses the nematode-induced mechanisms which may influence the metastatic process.
- Published
- 2020
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