1. Immune response in Dobrava-Belgrade virus infections
- Author
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Katerina Tsergouli and Anna Papa
- Subjects
Adult ,Male ,0301 basic medicine ,Orthohantavirus ,medicine.medical_specialty ,Hemorrhagic Fever With Renal Syndrome ,Vascular permeability ,macromolecular substances ,Disease ,Hantavirus Pulmonary Syndrome ,Biology ,Severity of Illness Index ,Virus ,Puumala Virus ,Young Adult ,03 medical and health sciences ,Th2 Cells ,Immune system ,Medical microbiology ,Virology ,Severity of illness ,medicine ,Humans ,Aged ,Hantavirus ,VEGF Level ,Greece ,Fatal Case ,General Medicine ,Middle Aged ,Th1 Cells ,Dobrava-Belgrade virus ,biology.organism_classification ,3. Good health ,Hospitalization ,030104 developmental biology ,Immunology ,Cytokines ,Female ,Original Article - Abstract
Dobrava-Belgrade virus (DOBV) is a hantavirus that causes a disease in humans known as hemorrhagic fever with renal syndrome. Hallmarks of hantaviral infections are increased vascular permeability due to dysregulation of the endothelial cell barrier and acute thrombocytopenia. In order to gain insight into the immune response in DOBV infections, the serum levels of 27 cytokines in 24 hospitalized Greek HFRS patients were evaluated. Compared to the control group, significantly higher IL-1ra, IL-6, IL-8, IL-9, IL-10, GM-CSF, IP-10, MIP-1b, TNF-α and VEGF levels were found in severe cases, while in non-severe cases, IL-13 and TNF-α levels were significantly higher (p
- Published
- 2016
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