1. Functional effector memory T cells contribute to protection from superinfection with heterologous simian immunodeficiency virus or simian-human immunodeficiency virus isolates in Chinese rhesus macaques
- Author
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Bingxiang Li, Jingjing Wang, Longding Liu, Haiting Long, Ge Guo, Lei Guo, Yingpeng Xie, Ruotong Ning, Ming Sun, Huiwen Zheng, and Yue Li
- Subjects
CD4-Positive T-Lymphocytes ,Male ,0301 basic medicine ,viruses ,030106 microbiology ,Simian Acquired Immunodeficiency Syndrome ,Heterologous ,CD8-Positive T-Lymphocytes ,Biology ,Antibodies, Viral ,medicine.disease_cause ,Virus ,03 medical and health sciences ,Immune system ,Virology ,parasitic diseases ,medicine ,Animals ,Neutralizing antibody ,Effector ,virus diseases ,General Medicine ,Viral Load ,biochemical phenomena, metabolism, and nutrition ,Simian immunodeficiency virus ,Antibodies, Neutralizing ,Macaca mulatta ,Disease Models, Animal ,030104 developmental biology ,Superinfection ,Immunology ,biology.protein ,Female ,Simian Immunodeficiency Virus ,Antibody ,Immunologic Memory - Abstract
Many studies have revealed a protective effect of infection of an individual with an immunodeficiency virus against subsequent infection with a heterologous strain. However, the extent of protection against superinfection conferred by the first infection and the biological consequences of superinfection are not well understood. Here, we report that a rhesus monkey model of mucosal superinfection was established to investigate the protective immune response. Protection against superinfection was shown to correlate with the extent of the polyfunctionality of CD4+ effector memory T cells, whereas neutralizing antibody responses did not protect against superinfection in this model. Notably, immunodeficiency-virus-associated effector memory T-cell responses might significantly contribute to the suppression of virus superinfection. This provides a potential theoretical basis for the development of an HIV/AIDS vaccine.
- Published
- 2017
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