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Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases regulated by endogenous tissue inhibitors of metalloproteinases (TIMPs). TIMP-1 is overexpressed in several types of human neoplasms. Tissue expression of TIMP-1 was evaluated in 41 samples of canine cutaneous mast cell tumors. The percentage of immuno-positive cells for TIMP-1 was compared with histopathological grading. The cytoplasmic expression of TIMP-1 in mast cells were positive (100%) of tumors examined. The mast cell classified as less differentiated by Patnaik showed higher expression of TIMP-1 (P <0.05 between stages I and III). These results suggest that expression of TIMP-1 may be a potential prognostic marker for the canine cutaneous mast cell tumors. [ABSTRACT FROM AUTHOR]

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The acquired capabilities defining neoplasms comprise useful tools to improve diagnosis and prognosis. In humans, proliferation is the single most important malignancy criterion in the adrenocortical tumors. In this study we compared histomorphological features and the proliferative activity in 28 ferret adrenocortical nodular lesions. The proliferative activity was assessed immunohistochemically proliferating cell nuclear antigen [PCNA]; Ki-67) or stained for argyrophilic nucleolar organizer regions [AgNORs]). All the three parameters indicate a significant difference between benign (adrenocortical nodular hyperplasias and adenomas), and malignant lesions (carcinomas), suggesting a correlation with adrenal malignancies in other species, like humans and dogs. [ABSTRACT FROM AUTHOR]

Copyright of Archives of Veterinary Science is the property of Archives of Veterinary Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Archives of Veterinary Science is the property of Archives of Veterinary Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)