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1. Relative induction of molecular forms of cytochrome P-450 in gamma-hexachlorocyclohexane exposed rat liver microsomes

Author

Ashwani Kumar and P.P. Dwivedi

Subjects
Male, Cytochrome, Health, Toxicology and Mutagenesis, Blotting, Western, Hexachlorocyclohexane, Biology, Toxicology, chemistry.chemical_compound, Cytochrome P-450 Enzyme System, Immunochemistry, Cytochrome P-450 CYP1A1, Animals, Inducer, Enzyme inducer, Cytochrome P450, Rats, Inbred Strains, General Medicine, Molecular biology, Rats, Blot, Biochemistry, chemistry, Enzyme Induction, Toxicity, biology.protein, Microsomes, Liver, Oxidoreductases
Abstract

The effect of gamma-hexachlorocyclohexane (HCH), (25 mg/kg body weight, i.p., administered for 4 consecutive days) on the induction of types of cytochrome P-450 in rat liver microsomes was studied. Induced proteins were characterized by "Western" blot analysis, using anticytochrome P-450 antibodies. It was observed that HCH is a "mixed-type" inducer and mediates induction of cytochrome P-450 b/e forms by several fold and of cytochrome P-450 c and d forms by nearly three fold.

Published
1988

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