1. Cytotoxic 10-(indol-3-yl)-[13]cytochalasans from the fungus Chaetomium elatum ChE01.
- Author
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Thohinung S, Kanokmedhakul S, Kanokmedhakul K, Kukongviriyapan V, Tusskorn O, and Soytong K
- Subjects
- Bile Duct Neoplasms drug therapy, Bile Duct Neoplasms pathology, Bile Ducts, Intrahepatic pathology, Breast Neoplasms pathology, Cell Line, Tumor, Cholangiocarcinoma pathology, Drug Screening Assays, Antitumor, Female, Humans, Indole Alkaloids administration & dosage, Indole Alkaloids isolation & purification, Inhibitory Concentration 50, Breast Neoplasms drug therapy, Chaetomium chemistry, Cholangiocarcinoma drug therapy, Indole Alkaloids pharmacology
- Abstract
Nine 10-(indol-3-yl)-[13]cytochalasans such as a new chaetoglobosin V (1); two new natural products, prochaetoglobosin III (2) and prochaetoglobosin III(ed) (3); six known chaetoglobosins B-D (4-6), F (7), and G (8) and isochaetoglobosin D (9) in addition to two known sterols, 24(R)-5alpha,8alpha-epidioxyergosta-6-22-diene-3beta-ol (10) and ergosterol (11), were isolated from the fungus Chaetomium elatum ChE01. The structures of these compounds were elucidated by spectroscopic methods. Compounds 1-9 showed cytotoxicity against the human breast cancer (IC(50) 2.54-21.29 microM) and cholangiocarcinoma cell lines (IC(50) 3.41-86.95 microM).
- Published
- 2010
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