1. Bioactive prenylated flavonoids from the stem bark of Artocarpus kemando.
- Author
-
Seo EK, Lee D, Shin YG, Chai HB, Navarro HA, Kardono LB, Rahman I, Cordell GA, Farnsworth NR, Pezzuto JM, Kinghorn AD, Wani MC, and Wall ME
- Subjects
- Cell Survival drug effects, Chromatography, High Pressure Liquid, Drug Screening Assays, Antitumor, Humans, Indonesia, Inhibitory Concentration 50, KB Cells, Molecular Structure, Plant Bark chemistry, Plant Extracts chemistry, Antineoplastic Agents, Phytogenic chemistry, Antineoplastic Agents, Phytogenic isolation & purification, Antineoplastic Agents, Phytogenic pharmacology, Artocarpus chemistry, DNA, Neoplasm drug effects, Flavonoids chemistry, Flavonoids isolation & purification, Flavonoids pharmacology
- Abstract
Four known prenylated flavonoids, artonins E (1) and O (2), artobiloxanthone (3), and cycloartobiloxanthone (4), were isolated from the stem bark of Artocarpus kemando by bioassay-guided fractionation using the DNA strand-scission and the KB cytotoxicity assays as monitors. Compounds 1 and 3 exhibited strong DNA strand-scission activity, and all four compounds were found to be cytotoxic.
- Published
- 2003
- Full Text
- View/download PDF