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Whole slide imaging involves high-resolution scanning of glass slides (GSs) prepared from formalin-fixed, paraffin-embedded tissue to create digital images that can be reviewed through digital platforms. The main components of [...], * Context.--In the United States, review of digital whole slide images (WSIs) using specific systems is approved for primary diagnosis but has not been implemented for intraoperative consultation. Objective.--To evaluate the safety of review of WSIs and compare the efficiency of review of WSIs and glass slides (GSs) for intraoperative consultation. Design.--Ninety-one cases previously submitted for frozen section evaluation were randomly selected from 8 different anatomic pathology subspecialties. GSs from these cases were scanned on a Leica Aperio AT2 scanner at x 20 magnification (0.25 [micro]m/pixel). The slides were deidentified, and a short relevant clinical history was provided for each slide. Nine board-certified general pathologists who do not routinely establish primary diagnoses using WSIs reviewed the WSIs using Leica Aperio ImageScope viewing software. After a washout period of 2-3 weeks, the pathologists reviewed the corresponding GSs using a light microscope (Olympus BX43). The pathologists recorded the diagnosis and time to reach the diagnosis. Intraobserver concordance, time to diagnosis, and specificity and sensitivity compared to the original diagnosis were evaluated. Results.--The rate of intraobserver concordance between GS results and WSI results was 93.7%. Mean time to diagnosis was 1.25 minutes for GSs and 1.76 minutes for WSIs (P < .001). Specificity was 91% for GSs and 90% for WSIs; sensitivity was 92% for GSs and 92% for WSIs. Conclusions.--Time to diagnosis was longer with WSIs than with GSs, and scanning GSs and uploading the data to whole slide imaging systems takes time. However, review of WSIs appears to be a safe alternative to review of GSs. Use of WSIs allows reporting from a remote site during a public health emergency such as the COVID-19 pandemic and facilitates subspecialty histopathology services. (Arch Pathol Lab Med. 2024;148:715-721; doi: 10.5858/arpa.2023-0105-OA)

The recently revised WHO Classification of Tumours of the Central Nervous System (4th edition, 2007) follows in the highly successful footsteps of previous editions of this widely used reference. (1-3) [...]

In this issue of the ARCHIVES, 4 significant areas of advancement in the clinical diagnosis and classification of brain tumors are highlighted: (1) newly recognized types of mixed glioneuronal tumors, [...]

The article announces the top five abstracts submitted by Junior Members of the College of American Pathologies (CAP) to the CAP 2006 meeting. They include Martin P. Powers' "Cytokine Gene Polymorphisms in Patients With a Myelodysplastic Phenotype," Maria Gallego Attis' "Mitotic Rate in Melanoma: A Reexamination," and Owen T.M. Chan's "Placental Pathology of Twin Pregnancies Derived From Spontaneous Conception and Assisted Reproductive Technology."