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• A 40-year-old man had a small choroidal melanoma in his left eye. The tumor was seemingly erradicated by xenon arc photocoagulation; however, eight years later the tumor recurred along the inferior edge of the chorioretinal scar, and the eye was enucleated. Histopathologic examination of the lesion revealed a spindle B-cell melanoma.

• Of 122 patients with corneoscleral lacerations repaired during a four-year period, 21 (17%) underwent enucleation primarily or within ten days of injury, 85 (70%) had at least six months of followup, and 16 (13%) were unavailable for follow-up. The most significant predictors of enucleation were poor initial visual acuity, the amount of hyphema, the presence of posterior uveal prolapse or vitreous hemorrhage, the extent of lens damage, and the length of laceration. The most significant predictors of a good visual outcome were good initial visual acuity, absence of hyphema, absence of posterior uveal prolapse or vitreous hemorrhage, and length of laceration. Final astigmatism was greater if the corneal wound was 4 mm or longer. Delaying the initial repair up to 36 hours had no effect on outcome.

• Preretinal neovascularization in response to retinal vascular occlusions developed in two patients receiving treatment for systemic lupus erythematosus. In both patients, the preretinal neovascularization was asymptomatic and was discovered on routine ocular examination. One patient required bilateral peripheral ablative argon-laser therapy for florid preretinal neovascularization. This patient had severe occlusive retinal vasculitis despite serologic evidence of remission of the underlying disease process.

• Four cases of the simultaneous occurrence of bilateral diffuse melanocytic uveal tumors were studied by us. In each case, the patient had an associated systemic malignant neoplasm diagnosed by biopsy or at autopsy. There was no evidence of metastatic melanoma in any patient. Clinically, the patients experienced rapid loss of vision, and cataracts were usually present. Multiple pigmented and nonpigmented placoid iridic and choroidal nodules, as well as serous retinal detachment, frequently were noted. Histopathologically, the uveal tracts of both eyes were diffusely infiltrated by preponderantly benign-appearing nevoid or spindle-shaped cells. Areas of necrosis within the tumors and scleral involvement were commonly seen. We believe this constellation of findings constitutes a new syndrome in which there is a bilateral, diffuse proliferation of melanocytic cells throughout the uvea in association with a systemic malignant neoplasm.