1. Role of the HLA System in the Association Between Multiple Sclerosis and Infectious Mononucleosis
- Author
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Dorothy H. Crawford, Karen A. McAulay, George C. Ebers, Margaret Conacher, Ute C. Meier, Sreeram V. Ramagopalan, and Gavin Giovannoni
- Subjects
Herpesvirus 4, Human ,medicine.medical_specialty ,Multiple Sclerosis ,Genotype ,Mononucleosis ,Cohort Studies ,Arts and Humanities (miscellaneous) ,Risk Factors ,Internal medicine ,medicine ,HLA-B Antigens ,Humans ,Infectious Mononucleosis ,Prospective Studies ,Seroconversion ,Prospective cohort study ,HLA-DQB1 ,HLA-A Antigens ,business.industry ,Multiple sclerosis ,Odds ratio ,Viral Load ,medicine.disease ,Haplotypes ,Immunology ,Neurology (clinical) ,business ,HLA-DRB1 Chains ,Cohort study - Abstract
OBJECTIVE: To determine whether multiple sclerosis (MS) and infectious mononucleosis (IM) share common HLA associations. DESIGN: A prospective cohort study was conducted from October 1, 1999, through September 30, 2003. SETTING: University of Edinburgh Richard Verney Health Centre, Edinburgh, Scotland. PATIENTS: Participants included 179 individuals who underwent asymptomatic Epstein-Barr virus seroconversion and 175 patients who developed IM. INTERVENTION: Genotyping for 5 classical HLA loci (HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1). MAIN OUTCOME MEASURE: Diagnosis of IM and allele frequency. RESULTS: Allelic analysis showed that HLA-DRB1*01:01 was significantly associated with the development of IM (odds ratio, 3.2; P < .001). Patients with IM and HLA-DRB1*01:01 had a lower Epstein-Barr virus viral load compared with those without the allele (median, 783 vs 7366 copies/10(6) peripheral blood mononuclear cells; P = .03). CONCLUSION: HLA-DRB1*01:01 is protective against developing MS; thus, a common genetic basis between IM and MS is not supported.
- Published
- 2011
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