1. Granulomatous amoebic meningoencephalitis in an immunocompetent patient
- Author
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Rodrigo Alencar e Silva, Stanley de Almeida Araújo, José Teotônio de Oliveira, Izabela Faria de Freitas e Avellar, Paulo Pereira Christo, and José Eymard Homem Pittella
- Subjects
Pathology ,medicine.medical_specialty ,Tomography Scanners, X-Ray Computed ,Balamuthia mandrillaris ,Central nervous system disease ,Cerebrospinal fluid ,Arts and Humanities (miscellaneous) ,Meningoencephalitis ,Cerebellum ,Biopsy ,medicine ,Humans ,Granulomatous amoebic encephalitis ,Granuloma ,biology ,medicine.diagnostic_test ,business.industry ,Amebiasis ,Middle Aged ,biology.organism_classification ,medicine.disease ,Magnetic Resonance Imaging ,Female ,Neurology (clinical) ,Immunocompetence ,business ,Encephalitis - Abstract
Objective To report a case of granulomatous amoebic encephalitis caused byBalamuthia mandrillaris. Design Case report. Setting University hospital. Patients An adult female patient without any apparent suppressor immune system factor had central nervous system infection caused byB mandrillaris. Main Outcome Measures Clinical, neuroimaging, and pathology findings. Results This study shows the diagnosis ofB mandrillarisencephalitis suspected from a cerebral biopsy specimen and confirmed by immunohistochemical and polymerase chain reaction studies. Conclusions This study demonstrates that the diagnosis of amoebic encephalitis represents a clinical challenge and confirming diagnoses are made, in most cases, after death. High suspicion, histopathologic examination, and indirect immunofluorescence, polymerase chain reaction, and cytokine studies from tissue and cerebrospinal fluid are the main devices to reach the diagnosis.
- Published
- 2010