7 results on '"Faught E"'
Search Results
2. Self-induced Photosensitive Absence Seizures With Ictal Pleasure
- Author
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Faught, E., primary, Falgout, J., additional, Nidiffer, F. D., additional, and Dreifuss, F. E., additional
- Published
- 1986
- Full Text
- View/download PDF
3. Race/ethnicity, sex, and socioeconomic status as predictors of outcome after surgery for temporal lobe epilepsy.
- Author
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Burneo JG, Black L, Martin R, Devinsky O, Pacia S, Faught E, Vasquez B, Knowlton RC, Luciano D, Doyle W, Najjar S, and Kuzniecky RI
- Subjects
- Adult, Cohort Studies, Epilepsy, Temporal Lobe physiopathology, Female, Humans, Male, Middle Aged, Multicenter Studies as Topic, Prospective Studies, Racial Groups, Risk Factors, Sex Factors, Treatment Outcome, Epilepsy, Temporal Lobe ethnology, Epilepsy, Temporal Lobe surgery, Ethnicity ethnology, Social Class
- Abstract
Background: Several risk factors have been attributed to seizure recurrence after surgery. It is unknown whether race/ethnicity plays a role in outcome., Objective: To evaluate whether race/ethnicity plays a role in seizure recurrence after surgery., Design: Cohort study., Setting: We evaluated data obtained from the epilepsy centers at the University of Alabama at Birmingham and New York University, New York, NY., Patients: All patients included had a diagnosis of mesial temporal sclerosis and underwent temporal lobectomy., Main Outcome Measures: Occurrence of seizure after surgery was registered 1 year after surgery. We used multiple logistic regression analysis to model the presence of seizure recurrence after surgery and generated odds ratios (ORs) for seizure recurrence after surgery for African American and Hispanic patients relative to white patients. An unadjusted model incorporated only race/ethnicity as the independent variable, and an adjusted model included socioeconomic status, age, duration of epilepsy, education, history of febrile seizures, sex, handedness, lateralization of epileptogenic focus, and number of antiepileptics as the independent variables., Results: Two hundred fifty-two patients underwent surgical treatment with pathological confirmation of mesial temporal sclerosis. No differences were found between racial/ethnic groups in terms of seizure recurrence in any models. For African American patients, the ORs were 0.9 (95% confidence interval [CI], 0.4-2.1) for the unadjusted model and 0.8 (95% CI, 0.3-2.0) for the adjusted model; for Hispanic patients, the ORs were 1.6 (95% CI, 0.8-3.2) for the unadjusted model and 1.1 (95% CI, 0.5-2.6) for the adjusted model, relative to white patients., Conclusion: Our data suggest that although sex appears to play a role in the outcomes of surgery for temporal lobe epilepsy, race and socioeconomic status do not.
- Published
- 2006
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4. Significance of fornix atrophy in temporal lobe epilepsy surgery outcome.
- Author
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Burneo JG, Bilir E, Faught E, Morawetz R, Knowlton RC, Martin R, and Kuzniecky RI
- Subjects
- Adolescent, Adult, Atrophy pathology, Female, Functional Laterality, Hippocampus pathology, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neurosurgical Procedures, Preoperative Care, Severity of Illness Index, Treatment Outcome, Epilepsy, Temporal Lobe pathology, Epilepsy, Temporal Lobe surgery, Fornix, Brain pathology
- Abstract
Background: Previous magnetic resonance imaging (MRI) studies have shown concurrent fornix atrophy in a large proportion of patients with hippocampal atrophy. The contribution of the fornix as an independent preoperative determinant of surgical outcome is unknown., Objective: To evaluate the contribution of the fornix as a determinant of surgical outcome in patients with preoperatively determined temporal lobe epilepsy., Methods: We selected 78 patients who had undergone anterior temporal lobectomy for intractable temporal lobe epilepsy at the University of Alabama at Birmingham Epilepsy Center during a 24-month period. All patients underwent standard presurgical investigations and intracranial investigations when needed. Magnetic resonance imaging volumetric studies were performed prior to surgery using previously published techniques. Patients were assessed regularly for postoperative seizure control. Outcome after at least 3 years was evaluated using Engel's classification for epilepsy. The chi2 test was used to compare categorical data., Results: Seventy-eight patients were included in this study. Eight patients were excluded because of inadequate follow-up. Thirty-five patients (44.9%) had unilateral isolated hippocampal atrophy exclusively on MRI volumetry, 29 (37.2%) had unilateral hippocampal atrophy with ipsilateral fornix atrophy, and 6 (7.7%) had isolated fornix atrophy without hippocampal atrophy. Twenty-eight patients (80%) in the unilateral hippocampal atrophy group were seizure free (ie, Engel class 1: patients who are completely seizure free with no aura and who do not receive antiepileptic drugs) compared with 21 patients (73%) in the fornix and hippocampal atrophy group (P =.57). All 6 patients with isolated fornix atrophy achieved an Engel's class 1 outcome., Conclusions: These findings suggest that identification of fornix atrophy with or without associated hippocampal atrophy is not an important preoperative determinant of surgical outcome. However, in the presence of a normal hippocampus, fornix atrophy may be valuable in predicting seizure-free outcome.
- Published
- 2003
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5. Temporal lobectomy in congenital porencephaly associated with hippocampal sclerosis.
- Author
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Burneo JG, Faught E, Knowlton RC, Martin RC, Bebin M, Morawetz R, and Kuzniecky R
- Subjects
- Adolescent, Adult, Brain Diseases congenital, Electroencephalography, Female, Humans, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Sclerosis, Treatment Outcome, Brain Diseases surgery, Epilepsy, Temporal Lobe surgery, Hippocampus pathology, Neurosurgical Procedures, Temporal Lobe surgery
- Abstract
Background: Clinical and neuroimaging features of patients with epilepsy and coexisting extratemporal porencephaly and hippocampal sclerosis have been previously described., Objective: To present the clinical characteristics and surgical outcome of 6 patients with intractable epilepsy and coexisting extratemporal porencephaly and hippocampal sclerosis., Patients and Methods: Twenty-four patients with porencephaly and epilepsy were studied. Of these, 6 had an epileptogenic focus in the temporal region. All patients underwent video electroencephalogram monitoring, magnetic resonance imaging studies, and neuropsychological evaluation. Of the subset of patients with temporal lobe epilepsy, 1 patient underwent intracranial electroencephalogram monitoring. Temporal lobe resection was performed in 5 patients. Outcomes were evaluated using the Engel classification., Results: Freedom from seizures was achieved in all patients. Pathologic analysis of the resected tissue confirmed the presurgical diagnosis of mesial temporal sclerosis., Conclusion: Patients with extratemporal porencephaly and intractable seizures should be evaluated early and be considered for temporal lobectomy if clinical, magnetic resonance imaging, and electroencephalogram findings support the diagnosis of temporal lobe onset seizures.
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- 2003
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6. Risk to verbal memory following anterior temporal lobectomy in patients with severe left-sided hippocampal sclerosis.
- Author
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Martin RC, Kretzmer T, Palmer C, Sawrie S, Knowlton R, Faught E, Morawetz R, and Kuzniecky R
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- Adolescent, Adult, Analysis of Variance, Anterior Temporal Lobectomy statistics & numerical data, Confidence Intervals, Epilepsy, Temporal Lobe pathology, Epilepsy, Temporal Lobe surgery, Functional Laterality physiology, Humans, Middle Aged, Regression Analysis, Risk Factors, Sclerosis, Severity of Illness Index, Anterior Temporal Lobectomy adverse effects, Hippocampus pathology, Hippocampus surgery, Memory physiology, Verbal Learning physiology
- Abstract
Background: Previous investigations indicate low risk for memory loss following anterior temporal lobectomy (ATL) in patients with severe hippocampal sclerosis (HS) compared with patients with mild HS. However, these conclusions have been established primarily with group-level analyses., Objective: To investigate individual base rate risk for verbal memory loss following ATL in patients who have pathologically verified mild, moderate, or severe HS., Patients and Methods: One hundred fifteen patients with unilateral temporal lobe epilepsy (68 with left-sided and 47 with right-sided epilepsy) were included. Acquisition, retrieval, and recognition components of verbal memory, as measured by the California Verbal Learning Test, were assessed before and after ATL. Postoperatively, the degree of neuronal loss and reactive gliosis of the hippocampus was assessed via a 3-tiered rating system establishing mild, moderate, and severe pathologic features. Patients with preoperative magnetic resonance imaging-based evidence of lesions outside the mesial temporal area (side of surgical resection) were excluded., Results: Neither seizure laterality nor severity of HS was associated with preoperative verbal memory performance. Postoperatively, the left-sided ATL group demonstrated significant decline across the acquisition (P<.01), retrival (P<.001), and recognition (P<.001) verbal memory components compared with the right-sided ATL group. Patients who underwent left-sided ATL and had mild HS displayed the largest magnitude and percentage proportion of postoperative decline across all verbal memory components. However, 28 (48%) of the 58 patients who underwent left-sided ATL and who had moderate and severe HS displayed statistically reliable declines on retrieval aspects of verbal memory. Most patients undergoing right-sided ATL, regardless of the extent of hippocampal pathologic features, displayed no postoperative memory change., Conclusions: Substantial individual heterogeneity of memory outcome exists across groups of patients undergoing ATL, with various degrees of pathologically verified HS. Patients undergoing left-sided ATL who have mild HS seem at greatest risk for broad-spectrum verbal memory decline. However, when examining outcome on a patient-by-patient basis, many patients undergoing left-sided ATL who have moderate to severe HS were also vulnerable to verbal memory loss. This risk seems selective to a retrieval-based aspect of verbal memory.
- Published
- 2002
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7. Magnetic resonance spectroscopic imaging in temporal lobe epilepsy: neuronal dysfunction or cell loss?
- Author
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Kuzniecky R, Palmer C, Hugg J, Martin R, Sawrie S, Morawetz R, Faught E, and Knowlton R
- Subjects
- Adolescent, Adult, Brain Chemistry physiology, Cell Count, Epilepsy, Temporal Lobe surgery, Female, Hippocampus metabolism, Hippocampus pathology, Hippocampus surgery, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuroglia physiology, Neurons physiology, Prospective Studies, Epilepsy, Temporal Lobe pathology
- Abstract
Background: Magnetic resonance spectroscopy (MRS) has demonstrated consistent metabolic abnormalities in temporal lobe epilepsy. The reason for decreases in N-acetylated compounds are thought to be related to neuronal hippocampal cell loss as observed in hippocampal sclerosis. However, mounting evidence suggest that the N-acetylated compound decreases may be functional and reversible., Objective: To establish whether the metabolic changes measured by MRS correlate to hippocampal cell loss in temporal lobe epilepsy., Subjects and Methods: We prospectively performed quantitative hippocampal MR imaging volumetry and MRS imaging in 33 patients with intractable mesial temporal lobe epilepsy who were undergoing surgery. A neuronal-glial ratio of cornu ammonis and fascia dentata was obtained and correlated while validating the pathologic analysis by comparisons with specimens of age-matched autopsy control-case hippocampus (n = 14)., Results: The neuronal-glial ratio of the patient group was statistically significantly lower than in the control group for the cornu ammonis region (P<.001). Correlations of hippocampal volumes with cornu ammonis and neuronal-glial ratios revealed a significant interdependence (P<.01). However, correlations of the resected hippocampal creatine-N-acetylated compound ratio with the cornu ammonis or fascia dentata neuronal-glial ratios showed no significant interdependence (P>.8)., Conclusions: Our findings support the concept that the metabolic dysfunction measured by MRS imaging and the hippocampal volume loss detected by MR imaging volumetry do not have the same neuropathologic basis. These findings suggest that the MRS imaging metabolic measures reflect neuronal and glial dysfunction rather than neuronal cell loss as previously assumed.
- Published
- 2001
- Full Text
- View/download PDF
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