1. Comparison of Disease Phenotype and Course among Elderly- and Early-Onset Inflammatory Bowel Diseases in the Middle East.
- Author
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Vosoghinia, Hasan, Saberzadeh-Ardestani, Bahar, Anushiravani, Amir, Mansour-Ghanaei, Fariborz, Fakheri, Hafez, Vahedi, Homayoon, Sheikhesmaeili, Farshad, Yazdanbod, Abbas, Moosavy, Seyed Hamid, Maleki, Iradj, Nasseri-Moghaddam, Siavosh, Khosravi, Bardia, Malekzadeh, Masoud, Kasaeian, Amir, Alatab, Sudabeh, Sadeghi, Anahita, Kolahdoozan, Shadi, Amani, Mohammad, Saberhosseini, Seyedeh Naeimeh, and Rayatpisheh, Maryam
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INFLAMMATORY bowel disease treatment , *DISEASE progression , *CROHN'S disease , *ULCERATIVE colitis , *RELATIVE medical risk , *INFLAMMATORY bowel diseases , *PREDNISOLONE , *CONFIDENCE intervals , *RETROSPECTIVE studies , *ACQUISITION of data , *REGRESSION analysis , *IMMUNOMODULATORS , *COMPARATIVE studies , *AGE factors in disease , *MEDICAL records , *SYMPTOMS , *DISEASE duration , *DESCRIPTIVE statistics , *TUMOR necrosis factors , *RESEARCH funding , *DEMOGRAPHY , *PHENOTYPES , *LONGITUDINAL method , *DISEASE complications , *OLD age - Abstract
Background: It is unknown if the clinical manifestations and phenotype of disease are comparable between early- and elderlyonset inflammatory bowel disease (IBD). We aimed to seek differences in disease phenotype, course, complications, and treatment between early- and elderly-onset IBD patients. Methods: This retrospective cohort study on registered IBD patients in the Iranian Registry of Crohn's and Colitis (IRCC) compared demographics, disease phenotype, disease activity, IBD-related surgery and medications between early- and elderly-onset IBD. A generalized linear regression model was used to investigate the relative risk of age at diagnosis adjusted for gender and disease duration for the outcomes. Results: From 10 048 IBD patients, 749 with early-onset (7.5%), and 472 (4.7%) elderly-onset IBD were enrolled: 855 (63.1%) ulcerative colitis (UC) and 366 (26.9%) Crohn's disease (CD). Left-sided colitis was more frequent among elderly-onset UC patients (P < 0.001). Ileum and ileocolonic locations were the most common types in elderly-onset and early-onset CD patients, respectively. In comparison with elderly-onset UC, early-onset cases more often used prednisolone (22.1% vs. 11.4%, P = 0.001), immunomodulators (44.9% vs 25.2%, P < 0.001) and anti-tumor necrosis factors (TNF) (20.1% vs 11.9%, P = 0.002). Elderly-onset UC patients had 0.7 times lower risk of aggressive phenotype (95%CI:0.6-0.9, P = 0.005). Early-onset CD was associated with higher use of prednisolone (27.7% vs 8.1%, P < 0.001), immunomodulators (58.7% vs 41.8%, P = 0.005) and anti-TNF (49.6% vs 35.4%, P = 0.006). Conclusion: Early-onset IBD was associated with a more aggressive phenotype and higher prednisolone, immunomodulators, and anti-TNF use. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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