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• Serum vitamin D metabolites were measured in 160 normocalcemic urinary calcium stone formers and in 217 control subjects. No difference in concentrations of 25-hydroxyvitamin D (25[OH]D), 24,25-dihydroxyvitamin D (24,25[OH] 2 D), and 1,25-dihydroxyvitamin D (1,25[OH] 2 D) was found between stone formers and control subjects. Values for 25(OH)D and 24,25(OH) 2 D were higher in hypercalciuric stone formers than in normocalciuric stone formers independent of seasonal fluctuation. No difference in concentration of serum 1,25(OH) 2 D was found between hypercalciuric and normocalciuric stone formers. No correlations were present between the serum concentrations of the measured vitamin D metabolites and of measures of calcium and phosphate metabolism. These findings suggest no major pathophysiologic role of the main vitamin D metabolites in urinary calcium stone formation. ( Arch Intern Med 1985;145:681-684)

To the Editor. —In the February 1980 issue of theArchives(140:205-207), Rao et al report a series of patients with hyperparathyroidism (HPT) after head and neck irradiation with x-ray therapy. In the discussion, they mention the absence of reports on HPT after radioactive iodine (131I) therapy. Tisell et al,1however, in 1976, described a patient who experienced HPT nine years after131I therapy for hyperthyroidism. Our series of 77 patients with HPT contains two patients who received sodium iodide I 131 therapy 11 and 20 years before diagnosis of HPT because of toxic nodular goiter. In these same series, there are ten other patients with HPT and foregoing x-ray irradiation for benign diseases in childhood or adolescence. Report of Cases. —Case 1.—An 80-year-old woman was treated 11 years previously with 8 mCi of sodium iodide I 131 because of toxic nodular goiter. She was admitted to