1. Renin-angiotensin system and atherothrombotic disease: from genes to treatment
- Author
-
Douglas Jacoby and Daniel J. Rader
- Subjects
Arteriosclerosis ,Inflammation ,Angiotensin-Converting Enzyme Inhibitors ,Disease ,Pathogenesis ,Renin-Angiotensin System ,Risk Factors ,Renin–angiotensin system ,Internal Medicine ,medicine ,Animals ,Humans ,Endothelial dysfunction ,Growth Substances ,Clinical Trials as Topic ,Vascular disease ,business.industry ,Angiotensin II ,medicine.disease ,Human genetics ,Lipoproteins, LDL ,Oxidative Stress ,Immunology ,Endothelium, Vascular ,medicine.symptom ,business ,Signal Transduction - Abstract
The renin-angiotensin system plays a central role in the pathogenesis of cardiovascular disease. At the molecular and cellular levels, angiotensin II, the main effector peptide of the system, stimulates key components of atherosclerosis. Trials in animals and humans indicate that blocking renin-angiotensin system pathways decreases atherosclerotic plaque progression and ischemic events. This review provides a broad overview of the entire role of the renin-angiotensin system in atherothrombotic disease, ranging from molecular pathways to human genetics to the latest clinical trials.
- Published
- 2003