1. Association of interleukin-6 in women with persistence of DNA-HPV: a nested case-control study.
- Author
-
Rosa MI, Moraes MV, Vuolo F, Petronilho F, Bozzetti MC, Medeiros LR, Igansi CN, Silva FR, Dal-Pizzol F, and Rosa DD
- Subjects
- Adult, Brazil epidemiology, Case-Control Studies, Female, Humans, Interleukin-10 blood, Longitudinal Studies, Middle Aged, DNA, Viral blood, Interleukin-6 blood, Papillomavirus Infections blood, Papillomavirus Infections epidemiology
- Abstract
Objective: To identify the role of Interleukin-6, IL-10 and their epidemiological association in women with persistence of DNA-HPV., Design and Methods: A nested case-control study within a longitudinal cohort study. Cervical specimens and blood samples were collected at enrolment from asymptomatic women who looked for a service of public health in a district of Porto Alegre, Brazil. A logistic regression analysis was performed with 95% confidence intervals. The outcome was the persistence of DNA-HPV infection., Results: The analysis showed that the age of the first intercourse below 20 years old (OR = 19.65, IC 95% 2.43-68.85), four or more sexual partners during lifetime (OR = 5.67, IC 95% 1.28-24.99), women with a previous altered Pap smear (OR = 10.17, IC 95% 1.80-57.33), marital status (OR = 12.94, IC 95% 2.43-68.85) and IL6 ≤ 3.106 pg/ml were associated with persistence of HPV infection. IL-10 were not associated with the HPV persistence., Conclusion: The present study suggests that IL-6 levels may be a marker of HPV DNA persistence, although further investigation is necessary.
- Published
- 2012
- Full Text
- View/download PDF