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Start Over Author "Erdemoglu, E." Journal archives of gynecology and obstetrics
11 results on '"Erdemoglu, E."'

2. General gynecology

Author

Salfelder A., Lueken R. P., Bormann C., Gallinat A., Moeller C. P., Busche D., Nugent W., Krueger E., Nugent A., Caglar G., Tasci Y., Kayikcioglu F., Haberal A., Hasskamp Th., Krichbaum M., Aka N., Köse G., Sabah G., Sayharman E. S., Kumru P., Aka N., Karaca K., Köse G., Kumru P., Sayharman E. S., Haydardedeoglu B., Simsek E., Kilicdag E., Tarim E., Bagis T., Dede F. S., Dilbaz B., Dede H., Ilhan A. K., Haberal A., Dede F. S., Dilbaz B., Oral S., Erten A., Ilhan A. K., Haberal A., Ertas I. E., Kahyaoglu S., Turgay I., Tug M., Kalyoncu S., Batioglu S., Zorlu G., Arici C., Akar M. E., Ari E. S., Ari E., Erbay O. U., Caliskan M. O., Akar M. E., Simsek M., Taskm O., Gümüs Il., Turhan N. O., Arikan G., Giuliani A., Kelekci S., Yorgancioglu Z., Yilmaz B., Yasar L., Savan K., Sonmez S., Kart C., Vural M., Tanriverdi H. A., Cinar E., Barut A., Özbay K., Yardim T., Demir B., Kilinc N., Gul T., Erden A. C., Turgay I., Kahyaoglu S., Kokanali M. K., Batioglu S., Haydardedeoglu B., Simsek E., Kilicdag E. B., Tarim E., Aslan E., Bagis T., Seval M., Taskin S., Özmen B., Kahraman K., Yarci A., Tasci T., Unlü C., Taskin S., Seval M., Özmen B., Kahraman K., Gözükücük M., Kurt S., Unlü C., Taskin S., Özmen B., Bozaci E. A., Seval M., Ortac F., Yasar L., Sönmez A. S., Zebitay A. G., Gezer N., Yazicioglu H. F., Mehmetoglu G., Dede F. S., Dilbaz B., Kocak M., Dede H., Haberal A., Erten A., Ilhan A. K., Algül Y. L., Erden A. C., Yasar L., Zebitay A. G., Ozcan J., Duman O., Sonmez S., Yazicioglu F., Sensoy Y., Koc S., Cebi Z., Yasar L., Zebitay A. G., Özcan J., Duman O., Sönmez S., Yazicioglu F., Sensoy Y., Cebi Z., Zebitay A. G., Yasar L., Özcan J., Duman O., Sönmez S., Yazicioglu F., Sensoy Y., Koc S., Cebi Z., Zebitay A. G., Yasar L., Özcan J., Duman O., Sönmez S., Yazicioglu F., Sensoy Y., Cebi Z., Simsek M., Mendilcioglu I., Özekinci M., Ulukus M., Ulukus E. C., Seval Y., Cinar O., Zheng W., Arici A., Erkan L., Soylu F., Tatli O., Ozkent V., Dilbaz B., Ilhan A. K., Oral S., Dede H., Dogan A. R., Gün I., Erdemoglu E., Sargin H., Kamaci M., Dede F. S., Erten A., Sendag F., Akman L., Yucebilgin S., Karadadas N., Oztekin K., Bilgin O., Topuz S., Cigerli E., Iyibozkurt C. A., Akhan E. S., Saygili H., Berkman S., Bezircioglu I., Karakaya E., Baran N., Baloglu A., Aydin C., Hizli N., Cetinkaya B., Kavas A., Baloglu A., Cukurova K., Köksal A., Yetimalar H., Yildiz A., Ivit H., Keklik A., Pinar F., Aka N., Köse G., Tosun N., Kumru P., Tuncel T., Boynukalin K., Salman M. C., Ozyuncu O., Bozdag G., Ayhan A., Ates U., Usta T., Seyhan A., Ata B., Sidal B., Guler O. T., Salman M. C., Bozdag G., Ozyuncu O., Esin S., Ozyuncu O., Salman M. C., Bozdag G., Guven S., Gürban A., Gürban G., Özen S., Kirecci A., Özkesici B., Yücel S., Süer N., Erdemoglu E., Gün I., Sargin H., Erdemoglu C. E., Kamaci M., Akhan S. E., Citil I., Topuz S., Iyibozkurt C., Kesim M. D., Atis A., Aydin Y., Özpak D., Tashan F., Zeteroglu S., Kolusari A., Altunay H., Sahin H. G., Kamaci M., Kayikcioglu F., Erol O., Sarici S., Haberal A., Dingiloglu B. S., Güngör T., Özdal B., Cavkaytar S., Bilge Ü., Mollamahmutoglu L., Toprak Konca M., Özsoy S., Hekim N., Özel E., Senates M., Yener C., Göker N., Caliskan E., Filiz T., Yucesoy G., Coskun E., Vural B., Corakci A., Narin M. A., Caliskan E., Kayikcioglu F., Haberal A., Meydanli M. M., Kamaci M., Sahin H. G., Kolusari A., Yildizbas B., Bolluk G., Ates U., Usta T., Ata B., Seyhan A., Ozdemir B., Sidal B., Ünlü B. S., Aytan H., Evsen S., Tapisiz Ö L., Zergeroglu S., Zeteroglu S., Sahin H. G., Guler A., Kolusari A., Kamaci M., Altay M. M., Can A., Ungormus A., Polat A., and Haberal A.

Published
2005
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3. Maternal fetal medicine-perinatology

Author

Tekcan, C., Naki, M. M., Özcan, N., Cebi, M., Kanadikirik, F., Has, R., Aydoadu, M., Frenz, J. P., Schröder, W., Dede, F. S., Kovalak, E. E., Gelisen, O., Dede, H., Sariisik, B., Haberal, A., Caliskan, E., Turkoz, E., Corakci, A., Ozeren, S., Yucesoy, I., Terzioglu, N., Köhler, W., Feige, A., Atad, J., Auslender, R., Bardicef, M., Calderon, I., Leron, E., Abramovici, H., Ertas, I. F., Kahyaoglu, S., Turgay, M., Sut, N., Yilmaz, B., Ozel, M., Danisman, N., Kocak, I., Üstün, C., Bese, E., Ingec, M., Borekci, B., Yilmaz, M., Kadanali, S., Ingec, M., Kadanali, S., Erdogan, F., Kumtepe, Y., Gümüs, I. I., Turhan, N. O., Tamburaci, E., Gunduz, O., Akar, M., Simsek, M., Zorlu, G., Ingec, M., Borekci, B., Kadanali, S., Balci, O., Gezginc, K., Acar, A., Akyürek, C., Kocak, I., Üstün, C., Bese, E., Biri, A., Guler, I., Himmetoglu, O., Karaoguz, M. Y., Balci, Sevim, Tanriverdi, H. A., Usal, D., Cinar, E., Barut, A., Pilanci, B., Imren, A., Öztekin, D., Kurt, S., Tinar, S., Canoruc, N., Kale, A., Kale, E., Yalinkaya, A., Akdeniz, N., Gol, M., Tuna, B., Guclu, S., Altunyurt, S., Demir, N., Biri, A., Ciftci, B., Senol, E., Haznedarohlu, S., Gucuyener, K., Gursoy, R., Kahyaoglu, S., Turgay, I., Gocmen, M., Yilmaz, B., Neslihanoglu, R., Danisman, N., Kahyaoglu, S., Turgay, I., Gocmen, M., Yilmaz, B., Ozel, M., Danisman, N., Kahyaoglu, S., Turgay, I., Kokanali, M. K., Kunt, C., Yapar, E. G., Taskin, S., Yarci, A., Bozaci, E. A., Atabekoglu, C., Söylemez, F., Taskin, S., Seval, M., Bozaci, E. A., Özmen, B., Mammadova, S., Unlü, C., Seval, M., Taskin, S., Özmen, B., Güleryüz, D., Sahincioglu, Ö., Unlü, C., Öztürk, N., Yalvac, S., Caliskan, E., Erten, A., Dölen, I., Haberal, A., Gul, A., Cebeci, A., Gedikbasi, A., Erol, O., Ceylan, Y., Tekirdag, A. I., Onan, M. A., Turp, A., Kurdoglu, M., Gunaydin, G., Kurdoglu, Z., Guler, I., Erdem, A., Himmetoglu, O., Tulumbaci, O., Onan, M. A., Turkoglu, S., Kurdoglu, M., Boyaci, B., Tiras, M. B., Kurdoglu, Z., Gunaydin, G., Kadayifci, O., Demir, S. C., Ürünsak, I. F., Özgünen, T., Evrüke, I. C., Demir, S. C., Evrüke, I. C., Özgünen, T., Kadayifci, O., Güzel, A. B., Urünsak, I. F., Uckuyu, A., Ozcimen, E. E., Nisanoglu, O., Yanik, F., Akgun, S., Kuscu, E., Sayin, N. C., Canda, M. T., Ahmet, N., Kurt, I., Varol, F. G., Erkanli, S., Caliskan, K., Bagis, T., Kilicdag, E., Tarim, E., Kuscu, E., Tutuncu, L., Ardic, N., Mungen, E., Ergur, A. R., Yergok, Y. Z., Cölcimen, N., Sahin, H. G., Kamaci, M., Bezircioglu, I., Bicer, M., Uysal, D., Yigit, S., Baloglu, A., Bezircioglu, I., Bicer, M., Karci, L., Ozder, F., Baloglu, A., Has, R., Yüksel, A., Büyükkurt, S., Tatli, B., Kalelioglu, I., Kesim, M. D., Aydin, Y., Atis, A., Gezer, A., Erkan, S., Simsek, Y., Kahraman, N., Uludag, S., Altinok, T., Kale, A., Erdemoglu, M., Akdeniz, N., Ozcan, Y., Yalinkaya, A., Köse, G., Tuncel, T., Aka, N., Kumru, P., Güven, M. A., Ciragil, P., Tutuncu, L., Ozdemir, E., Mungen, E., Ergur, A. R., Yergok, Y. Z., Güven, M. A., Aktan, E., Bozkurt, K., Güven, M. A., Kilinc, M., Ekerbicer, H., Güven, M. A., Ceylaner, S., Ceylaner, G., Gul, D., Ertas, E., Güven, M. A., Ceylaner, S., Batukan, C., Ozbek, A., Demirpolat, G., Uzel, M., Basaran, A., Bozdag, G., Dagdelen, S., Gürlek, A., Beksac, S., Arici, Özkan A., Isparta, T., Dikis, F. C., Civas, S. B., Ispahi, C., Kalelioalu, I. K., Has, R., Yüksel, A., Gilbaz, E., Ibrahimoglu, L., Ermis, H., Yildirim, A., Dane, B., Yayla, M., Dane, C., Özek, M., Kalelioglu, I. K., Has, R., Yüksel, A., Gilbaz, E., Ibrahimoglu, L., Ermis, H., Yildirim, A., Dane, B., Yayla, M., Cem, Dane, Salih, Dural, Dane, C., Yayla, M., Dane, B., Cetin, A., Kiray, M., Dane, B., Yayla, M., Dane, C., Ataoglu, E., Döventas, Y., Delier, H., Has, R., Kalelioglu, I., Büyükkurt, S., Has, R., Kalelioglu, I. K., Yüksel, A., Gilbaz, E., Ibrahimoglu, L., Ermis, H., Yildirim, A., Has, R., Kalelioglu, I. K., Yüksel, A., Gilbaz, E., Ibrahimoglu, L., Ermis, H., Yildirim, A., Yildiz, A., Köksal, A., Celik, N., Yetimalar, H., Keklik, A., Ivit, H., Cukurova, K., Hizli, D., Dilbaz, S., Acer, N., Deveci, S., Dilbaz, B., Haberal, A., Cukurova, K., Köksal, A., Yilmaz, S., Ivit, H., Yildiz, A., Yetimalar, H., Keklik, A., Bicer, Bulbul M., Karakaya, E., Pehlivan, M., Baloglu, A., Caliskan, E., Doger, E., Duman, C., Turker, G., Ozeren, S., Yucesoy, I., Caliskan, E., Doger, E., Cakiroglu, Y., Corakci, A., Ozeren, S., Caliskan, E., Turkoz, E., Ozeren, S., Corakci, A., Ozkan, S., Yucesoy, I., Caliskan, E., Cakiroglu, Y., Dundar, D., Doger, E., Caliskan, S., Ozeren, S., Cukurova, K., Köksal, A., Ivit, H., Yetimalar, H., Yildiz, A., Keklik, A., Aksakalli, V., Cukurova, K., Köksal, A., Önal, G., Yildiz, A., Ivit, H., Keklik, A., Yetimalar, H., Kesim, M. D., Demirkaya, B. Ö., Atis, A., Yavuz, M., Bozkurt, T., Ozyuncu, O., Bozdag, G., Salman, M. C., Durukan, T., Beksac, S., Onderoglu, L., Deren, O., Ayhan, A., Tufekci, C., Karalök, H., Ilter, E., Cil, L., Karalök, A. E., Akyol, H., Kesim, M. D., Demirkaya, B. Ö., Atis, A., Oruc, Ö., Ekin, M., Ülku, M., Caglar, P., Demirel, C., Güngör, T., Mollamahmutoglu, L., Usta, T., Özdemir, B., Ates, U., Numanoglu, N., Seyhan, A., Sidal, B., Akdeniz, N., Kale, A., Erdemoglu, M., Ozcan, Y., Yalinkaya, A., Ozdemir, B., Numanoglu, N., Usta, T., Ortakuz, S., Seyhan, A., Sidal, B., Seyhan, A., Numanoglu, N., Usta, T., Ortakuz, S., Öztarhan, A., Özdemir, B., Dogan, O., Ilbaz, S., Kovalak, E. E., Tarcan, A., Sariisik, B., Sivaslioglu, A., Haberal, A., Cinar, E., Tanriverdi, H. A., Akbulut, V., Sade, H., Barut, A., Dede, A., Özel, M., Günaydin, S., Ertas, E., Danisman, N., Mollamahmutoglu, L., Ates, U., Seyhan, A., Atmaca, U., Ortakuz, S., Ata, B., Akar, S., Sidal, B., Tanriverdi, H. A., Akbulut, V., Usal, D., Cinar, E., Barut, A., Vural, B., Özkan, S., Costur, P., Dalcik, H., Filiz, S., Yücesoy, I., Erdemoglu, E., Kolusari, A., Sahin, H. G., Kamaci, M., Sahin, A. V., Vural, B., Özkan, S., Tas, A., Dalcik, C., Dalcik, H., Yücesoy, G., Unlubilgin, E., Caliskan, E., Demir, B., Dilbaz, S., Sonmezer, M., Haberal, A., Erdem, M., Turp, A., Gunaydin, G., Erdem, A., Sade, H., Tanriverdi, H. A., Gezer, S., Bayar, Ü., Barut, A., Demir, B., Demir, F., Yayla, M., Api, O., Aygün, E., Kars, B., Cengizoglu, B., Bulut, S., Turan, C., Unal, O., Api, O., Ünal, O., Karageyim, Y. K., Balcik, O., Kara, Ö., Dogance, U., Akil, A., Api, M., Balsak, D., Avci, M. E., Elveren, B., Hanhan, M., Kayhan, K., Tinar, S., Ispahi, C., Mollamahmutoglu, L., Güngör, T., Özdal, B., Cavkaytar, S., Özat, M., Demirel, C., Aksakal, O., Caliskan, E., Unlubilgin, E., Cakiroglu, Y., Dilbaz, B., Dilbaz, S., Dilbaz, S., Caliskan, E., Dilbaz, B., Ozdas, E., Filiz, T., Haberal, A., Asian, E., Tarim, E., Kilicdag, E., Haydardedeoglu, B., Kuscu, E., Asian, E., Kilicdag, E., Simsek, E., Bolat, F., Haydardedeoglu, B., Ocak, S., Zeteroglu, S., Deveci, A., Gungoren, A., Borazan, E., Hakverdi, A., Zeteroglu, S., Ocak, S., Deveci, A., Gungoren, A., Andi, A., and Hakverdi, A.

Published
2005
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4. Clinical relevance of objectifying colposcopy

Author

Giuseppe Filiberto Vercellino, Gerd Böhmer, Evrim Erdemoglu, Al-Hakeem Malak, Katharina Vasiljeva, Achim Schneider, Vito Chiantera, Vercellino, G., Erdemoglu, E., Chiantera, V., Vasiljeva, K., Malak, A., Schneider, A., and Böhmer, G.

Subjects
Adult, medicine.medical_specialty, Uterine Cervical Neoplasm, Adolescent, Biopsy, Objective sign, Uterine Cervical Neoplasms, Predictive Value of Test, Cervical intraepithelial neoplasia, Likelihood ratios in diagnostic testing, Sensitivity and Specificity, Severity of Illness Index, Exoscopy, Young Adult, Retrospective Studie, Predictive Value of Tests, Pregnancy, Medicine, Humans, Cervical Intraepithelial Neoplasia, Retrospective Studies, Colposcopy, medicine.diagnostic_test, business.industry, Medicine (all), Obstetrics and Gynecology, General Medicine, Middle Aged, medicine.disease, Uterine Cervical Dysplasia, Confidence interval, Surgery, Predictive value of tests, High Grade Cervical Intraepithelial Neoplasia, High grade cervical intraepithelial neoplasia, Female, Radiology, business, Sign (mathematics), Human
Abstract

Purpose: To evaluate the clinical value of four objective colposcopic criteria inner border, ridge sign, cuffed crypt openings and rag sign to diagnose cervical intraepithelial neoplasia grade 2 or worse (CIN 2+), using video exoscopy and to compare it to subjective graduating signs. Methods: Retrospective evaluation of video recordings of 444 patients, referred for diagnostic colposcopy, who underwent cervical biopsies, and if indicated loop excisions. Most severe histological diagnosis was recorded. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and likelihood ratios (LR) with 95 % confidence interval, for CIN 2+ were calculated. Results: Single biopsy, two biopsies and magnification-guided loop excision were performed in 60.8, 39.2 and 70.5 % of patients, respectively. Sensitivity, specificity, PPV and NPV to detect CIN 2+ were 19.3, 99.2, 98.3 and 35.8 %, for inner border sign; 53.1, 93.5, 94.7 and 47.6 %, for ridge sign; 51.5, 84.9, 88.2, and 44.3 %, for cuffed crypt openings, and 40.7, 96.4, 96.1 and 42.5 %, for rag sign, respectively. The positive likelihood ratio (LR+) was 26.7 and the negative likelihood ratio (LR−) was 0.81, for inner border sign; 8.2 and 0.5, for ridge sign; 3.41 and 0.57 for cuffed crypt openings; and 11.3 and 0.62 for rag sign, respectively. 90 % of CIN 2+ had at least one objective sign. Combination of any two objective signs significantly increased the LR of the presence of CIN 2+, and was clinically superior to any combination of graduating signs. Conclusion: Objective colposcopic criteria are clinically useful and significantly associated with CIN 2+.

Published
2014

5. A multicentric randomized study comparing two techniques of magnification assisted loop excision of high-grade cervical intraepithelial neoplasia: video exoscopy and colposcopy

Author

A. M. Dückelmann, Al-Hakeem Malak, Achim Schneider, Janine Richter, Katharina Vasiljeva, Vito Chiantera, Giuseppe Filiberto Vercellino, Gerd Böhmer, Inka Drechsler, Evrim Erdemoglu, Vercellino, G., Erdemoglu, E., Chiantera, V., Malak, A., Vasiljeva, K., Drechsler, I., Dückelmann, A., Richter, J., Schneider, A., and Böhmer, G.

Subjects
Adult, medicine.medical_specialty, Electrosurgery, Magnification, Uterine Cervical Neoplasms, Video-Assisted Surgery, Cervix Uteri, Exoscopy, law.invention, Young Adult, Postoperative Complications, Randomized controlled trial, Cervical intraepithelial neoplasia grade 2, law, Pregnancy, LEEP, Medicine, Humans, Volume removed, Loop excision, Prospective Studies, Aged, Colposcopy, Aged, 80 and over, medicine.diagnostic_test, business.industry, Obstetrics and Gynecology, General Medicine, Middle Aged, Uterine Cervical Dysplasia, Surgery, High Grade Cervical Intraepithelial Neoplasia, Colposcop, Female, Safety, Neoplasm Recurrence, Local, business
Abstract

Purpose: To compare loop excisions of cervical intraepithelial neoplasia grade 2 or worse (CIN 2+) under video exoscopy, or colposcopic guidance, with respect to safety and effectiveness. Methods: Prospective multicentric randomized trial of 300 patients, undergoing loop excision for CIN 2+ either under video exoscopy (group A) or colposcope (group B) guidance. Intra- and post-operative complications, resection margins, and removed cervical volume in both groups were evaluated. Results: 19.3% of patients in video exoscopy group and 15.5% in colposcopy group (p = 0.67) had transformation zone (TZ) 3. 45/151 (29.8%) of group A patients and 48/149 (32.2%) of group B patients underwent top-hat procedure, i.e., one superficial excision followed by one deeper removal of the endocervical tissue (p = 0.74). There was no difference in intra- and post-operative complications in the two groups. Positive endocervical resection margins (R0) were 9.9% in video exoscopy group and 8.7% in colposcopy group, respectively. Unclear endocervical resection margins (Rx) were 2.0% in both groups. Mean total excised cervical volume was 1.20 cubic centimeter (cc 3) in group A, and 1.24 cc3 in group B, respectively. Recurrent disease occurred in 2.3% of patients at 6 months follow-up. Conclusion: Magnification assisted loop excision of CIN 2+ is equally effective and safe under colposcopic and video exoscopy guidance. The latter technique could potentially offer an alternative treatment of CIN 2+ lesions for doctors unfamiliar with colposcope. © Springer-Verlag 2013.

Published
2013

6. What should be the goal for future development of colposcopy? Cons and pros of sensitivity and specificity.

Author

Vercellino GF and Erdemoglu E

Subjects
Female, Humans, Pregnancy, Colposcopy methods, Uterine Cervical Neoplasms diagnosis, Uterine Cervical Dysplasia diagnosis
Abstract

Purpose: To discuss what features of colposcopy should be developed for the future in different settings., Result: There are cons and pros of aiming sensitivity, negative predictive value and specificity and positive predictive value. In case of diagnosis and intervention, methods increasing the specificity and positive predictive value will help to decrease unnecessary interventions. Besides, HPV test is highly sensitive and has a good negative predictive value. It is usually available before colposcopy., Conclusion: Colposcopy can be used in a screening or diagnostic/interventional scenario. Aims to improve sensitivity or specificity may change according to the aim of colposcopy. However, in the presence of highly sensitive tests which are performed before colposcopy, first goal to improve for colposcopy can be specificity and positive predictive value.

Published
2015
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7. Clinical relevance of objectifying colposcopy.

Author

Vercellino GF, Erdemoglu E, Chiantera V, Vasiljeva K, Malak AH, Schneider A, and Böhmer G

Subjects
Adolescent, Adult, Biopsy, Female, Humans, Middle Aged, Predictive Value of Tests, Pregnancy, Retrospective Studies, Sensitivity and Specificity, Severity of Illness Index, Young Adult, Colposcopy methods, Uterine Cervical Neoplasms diagnosis, Uterine Cervical Dysplasia diagnosis
Abstract

Purpose: To evaluate the clinical value of four objective colposcopic criteria inner border, ridge sign, cuffed crypt openings and rag sign to diagnose cervical intraepithelial neoplasia grade 2 or worse (CIN 2+), using video exoscopy and to compare it to subjective graduating signs., Methods: Retrospective evaluation of video recordings of 444 patients, referred for diagnostic colposcopy, who underwent cervical biopsies, and if indicated loop excisions. Most severe histological diagnosis was recorded. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and likelihood ratios (LR) with 95% confidence interval, for CIN 2+ were calculated., Results: Single biopsy, two biopsies and magnification-guided loop excision were performed in 60.8, 39.2 and 70.5% of patients, respectively. Sensitivity, specificity, PPV and NPV to detect CIN 2+ were 19.3, 99.2, 98.3 and 35.8%, for inner border sign; 53.1, 93.5, 94.7 and 47.6%, for ridge sign; 51.5, 84.9, 88.2, and 44.3%, for cuffed crypt openings, and 40.7, 96.4, 96.1 and 42.5%, for rag sign, respectively. The positive likelihood ratio (LR+) was 26.7 and the negative likelihood ratio (LR-) was 0.81, for inner border sign; 8.2 and 0.5, for ridge sign; 3.41 and 0.57 for cuffed crypt openings; and 11.3 and 0.62 for rag sign, respectively. 90% of CIN 2+ had at least one objective sign. Combination of any two objective signs significantly increased the LR of the presence of CIN 2+, and was clinically superior to any combination of graduating signs., Conclusion: Objective colposcopic criteria are clinically useful and significantly associated with CIN 2+.

Published
2015
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8. A multicentric randomized study comparing two techniques of magnification assisted loop excision of high-grade cervical intraepithelial neoplasia: video exoscopy and colposcopy.

Author

Vercellino GF, Erdemoglu E, Chiantera V, Malak AH, Vasiljeva K, Drechsler I, Dückelmann AM, Richter J, Schneider A, and Böhmer G

Subjects
Adult, Aged, Aged, 80 and over, Cervix Uteri surgery, Electrosurgery, Female, Humans, Middle Aged, Neoplasm Recurrence, Local, Postoperative Complications, Pregnancy, Prospective Studies, Uterine Cervical Neoplasms pathology, Young Adult, Uterine Cervical Dysplasia pathology, Colposcopy, Uterine Cervical Neoplasms surgery, Video-Assisted Surgery, Uterine Cervical Dysplasia surgery
Abstract

Purpose: To compare loop excisions of cervical intraepithelial neoplasia grade 2 or worse (CIN 2+) under video exoscopy, or colposcopic guidance, with respect to safety and effectiveness., Methods: Prospective multicentric randomized trial of 300 patients, undergoing loop excision for CIN 2+ either under video exoscopy (group A) or colposcope (group B) guidance. Intra- and post-operative complications, resection margins, and removed cervical volume in both groups were evaluated., Results: 19.3 % of patients in video exoscopy group and 15.5 % in colposcopy group (p = 0.67) had transformation zone (TZ) 3. 45/151 (29.8 %) of group A patients and 48/149 (32.2 %) of group B patients underwent top-hat procedure, i.e., one superficial excision followed by one deeper removal of the endocervical tissue (p = 0.74). There was no difference in intra- and post-operative complications in the two groups. Positive endocervical resection margins (R0) were 9.9 % in video exoscopy group and 8.7 % in colposcopy group, respectively. Unclear endocervical resection margins (Rx) were 2.0 % in both groups. Mean total excised cervical volume was 1.20 cubic centimeter (cc³) in group A, and 1.24 cc³ in group B, respectively. Recurrent disease occurred in 2.3 % of patients at 6 months follow-up., Conclusion: Magnification assisted loop excision of CIN 2+ is equally effective and safe under colposcopic and video exoscopy guidance. The latter technique could potentially offer an alternative treatment of CIN 2+ lesions for doctors unfamiliar with colposcope.

Published
2014
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9. Comparison of the effects of laparoscopic bipolar electrocoagulation and intracorporeal suture application to ovarian reserve in benign ovarian cysts.

Author

Özgönen H, Erdemoglu E, Günyeli I, Güney M, and Mungan T

Subjects
Adolescent, Adult, Female, Humans, Laparoscopy, Ovary physiology, Young Adult, Electrocoagulation adverse effects, Hemostatic Techniques adverse effects, Ovarian Cysts surgery, Ovary surgery, Suture Techniques adverse effects
Abstract

Purpose: Aim of the present study is to determine the effects of bipolar electrocoagulation and intracorporeal suture on the ovarian reserve after ovarian cystectomy., Methods: Sixty patients aged 18-42 years old and with a persistent adnexal mass were recruited to the study. Patients were randomized into suture hemostasis group or bipolar hemostasis group. Laparoscopic ovarian cystectomy was performed to all patients. Hemostasis was obtained by bipolar coagulation in 30 patients and by intracorporeal sutures in 30 patients. Serum levels of FSH, LH, estradiol, inhibin B and ultrasonographic measurements (antral follicle count and ovarian volume) were analyzed and recorded at day 3 of menstrual cycle, 1 and 3 months after the surgery., Results: Basal FSH level measurement at the postoperative third month was significantly increased to 6.96 ± 1.86 mIU/ml (p < 0.05) in the bipolar electrocoagulation group. However, the decreased ovarian volume and antral follicle count was restored at the postoperative third month in the bipolar electrocoagulation group. Preoperative and postoperative FSH, LH, estradiol and inhibin B levels and ultrasonographic measurements were similar in the intracorporeal suture group., Conclusion: The unwanted effect of bipolar electrocoagulation on ovarian reserve is probably transient and causes minimal damage to ovary. FSH levels may be slightly elevated. Gentle use of bipolar electrocoagulation or intracorporeal are not found to effect ovarian reserve.

Published
2013
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10. Laparoscopic temporary clipping of uterine artery during laparoscopic myomectomy.

Author

Vercellino G, Erdemoglu E, Joe A, Hopfenmueller W, Holthaus B, Köhler C, Schneider A, Hasenbein K, and Chiantera V

Subjects
Adult, Blood Volume, Chi-Square Distribution, Female, Humans, Laparoscopy adverse effects, Laparoscopy methods, Leiomyoma pathology, Middle Aged, Statistics, Nonparametric, Time Factors, Ultrasonography, Uterine Artery diagnostic imaging, Uterine Artery surgery, Uterine Myomectomy adverse effects, Uterine Neoplasms pathology, Uterus blood supply, Blood Loss, Surgical prevention & control, Hemostasis, Surgical adverse effects, Leiomyoma surgery, Uterine Myomectomy methods, Uterine Neoplasms surgery
Abstract

Purpose: Our aim is to study the feasibility and effect of bilateral laparoscopic temporary occlusion of uterine arteries by special vascular clamps on blood loss during laparoscopic myomectomy., Methods: Of 166 women with symptomatic uterine myomas necessitating surgical intervention who wished to retain their uteri, 80 underwent laparoscopic uterine artery clipping and myomectomy (experimental group) and 86 received laparoscopic myomectomy only (control group). Main outcome measures were operating time, number and weight of leiomyomas, blood loss, Doppler examination of the uterine arteries and complications of procedure., Results: In the experimental group the median hemoglobin drop measured on day 3 postoperatively was 1.2 g/dl. In the control group the mean hemoglobin drop measured on day 3 postoperatively was 1.45 g/dl. The time needed to put the clips in place (the time from the opening of the retroperitoneum and the positioning of the clips) varied between 6 and 40 min. No patient required blood transfusion. There were no conspicuous complications., Conclusion: The use of the clips has proved to be statistically effective in reducing hemoglobin loss during laparoscopic myomectomy.

Published
2012
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11. Reduction of postoperative adhesions by trimetazidine: an experimental study in a rat model.

Author

Erdemoglu E, Seçkin B, Günyeli I, Güney M, Seçkin M, and Mungan T

Subjects
Animals, Female, Rats, Rats, Wistar, Severity of Illness Index, Uterus drug effects, Uterus injuries, Tissue Adhesions drug therapy, Trimetazidine therapeutic use, Vasodilator Agents therapeutic use
Abstract

Objective: Trimetazidine (TMZ) reduces intracellular acidosis and inhibits oxygen-derived free radicals and neutrophile infiltration in ischemia and hypoxia, which are the primary steps of adhesion formation. Our aim is to study the anti-adhesion potential of trimetazidine in a rat uterine horn model., Methods: Forty non-pregnant female Wistar-Albino rats were randomly assigned, with ten in each group, to receive 2 ml saline, or 5 mg/kg intraperitoneal trimetazidine postoperatively, and control and sham. TMZ was administered to TMZ postoperative group 5 mg/kg i.p. daily for 5 days after the operation. Both uterine horns were exposed, and then a 2 cm segment of the anti-mesenteric surface of both the uterine horns were traumatized in 10 spots with unipolar electrocautery for 2 s with a power of 50 Watts. All the animals were killed by lethal dose of ether on postoperative 14th day. Intraperitoneal adhesions were scored by clinical adhesion scoring system, and histological and morphometric analysis was performed., Results: Total adhesion score (TAS) of control group was 10 while the sham group was found to be 0. TAS of the placebo group that was given saline (TAS 5), and postoperative TMZ applied group (TAS 3.5) were significantly lower than the control group (p < 0.05). The severity scores of postoperative TMZ and sham groups were significantly smaller than the other groups (p < 0.05)., Conclusion: TMZ significantly reduced the extent and severity of horn adhesions. The promising efficacy demonstrated by the intraperitoneal TMZ in this model warrants further investigation in clinical trials focused on gynecological procedures.

Published
2012
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