1. Macrophage colony-stimulating factor (M-CSF) in first trimester maternal serum: correlation with pathologic pregnancy outcome.
- Author
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Eckmann-Scholz, Christel, Wilke, Christina, Acil, Yahya, Alkatout, Ibrahim, and Salmassi, Ali
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MACROPHAGE colony-stimulating factor , *FIRST trimester of pregnancy , *GESTATIONAL diabetes , *CHORIONIC gonadotropins , *PLACENTAL growth factor , *PLACENTA abnormalities , *CHROMOSOME abnormalities , *CHROMOSOMES , *COLONY-stimulating factors (Physiology) , *FETAL ultrasonic imaging , *PREMATURE infants , *KARYOTYPES , *LONGITUDINAL method , *EVALUATION of medical care , *PREGNANCY , *PREGNANCY proteins , *PRENATAL diagnosis , *DOWN syndrome - Abstract
Purpose: To determine correlations between macrophage colony-stimulating factor (MCSF) levels in maternal blood during first trimester screening with respect to normal and pathological pregnancies.Methods: This was a prospective single centre study. First trimester screening was performed according to FMF London certificates. Nuchal translucency, PAPP-A and free β-HCG were obtained as well as M-CSF serum levels in maternal blood. Fetal karyotyping was achieved by chorionic villi sampling.Results: 125 patients were enrolled in this study. 21 pregnancies had confirmed aberrant karyotypes. Trisomy 21 cases showed significantly elevated M-CSF levels of 270 ± 91 pg/ml (p = 0.032), whereas cases of trisomy 13 (183 ± 68 pg/ml) and trisomy 18 (143 ± 40 pg/ml) had low M-CSF levels. Furthermore M-CSF levels tended to be low in preterm deliveries, placental insufficiency and nicotine consumption. In cases with gestational diabetes M-CSF tended to be elevated. Furthermore we found a positive correlation between high free β-human chorionic gonadotropin (hcg) and MCSF values. There was no correlation between pregnancy associated plasma protein (PAPP-A) and M-CSF.Conclusions: M-CSF is a cytokine promoting placental growth and differentiation. M-CSF is known to be involved in the process of implantation in pregnancy. The role of M-CSF with respect to disturbed pregnancy outcomes such as placental insufficiency in normal or aberrant karyotypes, for example, is yet subject to further research. [ABSTRACT FROM AUTHOR]- Published
- 2016
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