1. Functional magnetic resonance imaging response as an early biomarker of cognitive decline in elderly patients with metabolic syndrome
- Author
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Gabriela Chiochetta, Alessandro Ferrari Jacinto, Fábio Gazelato de Mello Franco, Edson Amaro, Nadia Shigaeff, Vanessa de Albuquerque Citero, Maysa Seabra Cendoroglo, Universidade Federal de São Paulo (UNIFESP), Hosp Israelita Albert Einstein, and Universidade Estadual Paulista (Unesp)
- Subjects
Male ,Aging ,medicine.medical_specialty ,Health (social science) ,Audiology ,Neuropsychological Tests ,Neuropsychological assessment ,03 medical and health sciences ,Executive Function ,0302 clinical medicine ,Elderly ,medicine ,Verbal fluency test ,Dementia ,Humans ,Cognitive Dysfunction ,030212 general & internal medicine ,Cognitive decline ,Psychiatry ,Cognitive impairment ,Aged ,Aged, 80 and over ,Metabolic Syndrome ,medicine.diagnostic_test ,Brain ,Biomarker ,Middle Aged ,medicine.disease ,Metabolic syndrome ,Magnetic Resonance Imaging ,Case-Control Studies ,Biomarker (medicine) ,Female ,Geriatrics and Gerontology ,Psychology ,Functional magnetic resonance imaging ,Gerontology ,Functional magnetic resonance ,030217 neurology & neurosurgery ,Biomarkers - Abstract
Made available in DSpace on 2018-11-26T17:41:51Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-11-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Ministry of Health which, via Technical Area of Health of Aged (PROADI) Hospital Israelita Albert Einstein under Support Program for Institutional Development of Brazilian Unified National Health System (SUS) Objectives: We assessed whether potential changes in brain activation patterns of elderly individuals with metabolic syndrome (MetS) who were cognitively healthy (without mild cognitive impairment or dementia) were associated with cognitive decline in executive function in the short-term. Method: We analyzed 43 individuals (23 MetS, 20 controls) using a global geriatric evaluation, a neuropsychological battery, and task-related (attention) fMRI exam. Correlation analysis between the fMRI signal at baseline and cognitive impairment after 1 year was based on the voxel-based Pearson coefficient, corrected for multiple comparisons. Results: At baseline, MetS patients showed reduced brain response in frontal and parietal regions compared to controls. After one year, the MetS group also showed a decline in verbal fluency performance. fMRI response in the right dorsolateral prefrontal cortex and bilateral parietal lobes was negatively correlated with verbal fluency decline in the MetS group. Discussion: Our results provide an early biomarker of the possible development of cognitive impairment, particularly in the executive function, of elderly individuals suffering from MetS. These findings also point to an up or down regulation which could be interpreted as compensatory mechanism for possible brain tissue burden caused by MetS. Univ Fed Sao Paulo, Escola Paulista Med, Dept Psychiat, Rua Borges Lagoa 570, BR-04038030 Sao Paulo, SP, Brazil Hosp Israelita Albert Einstein, Rua Borges Lagoa 570, BR-04038030 Sao Paulo, SP, Brazil Hosp Israelita Albert Einstein, Ave Albert Einstein, Sao Paulo, Brazil Hosp Israelita Albert Einstein, Rua Madre Cabrini 462, BR-04020001 Sao Paulo, SP, Brazil Univ Estadual Sao Paulo Julio de Mesquita Filho, Fac Med Botucatu, Dept Internal Med, Rua Borges Lagoa 570, BR-04038030 Sao Paulo, SP, Brazil Univ Fed Sao Paulo, Escola Paulista Med, Dept Internal Med, Div Geriatr, Rua Francisco de Castro 105, BR-04020050 Sao Paulo, SP, Brazil Univ Estadual Sao Paulo Julio de Mesquita Filho, Fac Med Botucatu, Dept Internal Med, Rua Borges Lagoa 570, BR-04038030 Sao Paulo, SP, Brazil CAPES: 2009/12271-3
- Published
- 2016